TNFSF18 and TNFRSF18

Number of citations of the paper that reports this interaction (PMID 10074428)
35

Data Source:
HPRD (in vivo)

		TNFSF18	TNFRSF18
Gene Name		tumor necrosis factor (ligand) superfamily, member 18	tumor necrosis factor receptor superfamily, member 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding	Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	T Cell Proliferation Involved In Immune Response Signal Transduction Cell-cell Signaling Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		1 interactors: TNFRSF18	5 interactors: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3
Entrez ID		8995	8784
HPRD ID		04874	04879
Ensembl ID			ENSG00000186891
Uniprot IDs		Q9UNG2	Q9Y5U5
PDB IDs		2Q1M 2R30 2R32 3B93 3B94
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway	Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cytokine-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Response To Cytokine Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Protein Complex Assembly Cell Death Death Regulation Of Innate Immune Response Protein Homooligomerization Negative Regulation Of Glial Cell Apoptotic Process Immune Response Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Protein Homodimerization Activity T Cell Proliferation Involved In Immune Response Toll Signaling Pathway Cellular Response To Nitric Oxide Regulation Of Cell-cell Adhesion Regulation Of Immunoglobulin Secretion Regulation Of Lymphocyte Activation Response To Nitric Oxide Protein Oligomerization Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Cytokine Production Protein Homotrimerization Regulation Of Protein Homodimerization Activity Cellular Response To Organic Substance Cellular Response To Reactive Nitrogen Species
Tagcloud ?		12rbeta2 24h 31ra amp amps angiogenic apm atopic autoimmunity ccl24 ccl25 ccl26 ccl3l1 ccl8 chemokines chemotaxis cxcl16 cxcl6 delineate dermatitis glucocorticoid hacat ige keratinocyte lymphotoxin osmr s100s toll vegfa	br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew icam3 igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf vegfa vegfc
Tagcloud (Difference) ?		12rbeta2 24h 31ra amp amps angiogenic apm atopic autoimmunity ccl24 ccl25 ccl26 ccl3l1 ccl8 chemokines chemotaxis cxcl16 cxcl6 delineate dermatitis glucocorticoid hacat ige keratinocyte lymphotoxin osmr s100s toll	br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew icam3 igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf vegfc
Tagcloud (Intersection) ?		vegfa