TNFSF18 and TNFRSF18

Number of citations of the paper that reports this interaction (PubMedID 10074428)
0

Data Source:
HPRD (in vivo)

		TNFSF18	TNFRSF18
Description		TNF superfamily member 18	TNF receptor superfamily member 18
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding	Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Migration Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 27182965 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 22057235 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)	Inflammatory bowel disease ( 23128233)
Interacting Genes		2 interacting genes: EXOC3L2 TNFRSF18	6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2
Entrez ID		8995	8784
HPRD ID		04874	04879
Ensembl ID		ENSG00000120337	ENSG00000186891
Uniprot IDs		A0A0U5JXL4 Q9UNG2	A0A0R7FDM1 Q9Y5U5
PDB IDs		2Q1M 2R30 2R32 3B93 3B94 7KHD 7LAW	7KHD 7LAW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Leukocyte Migration Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Tumor Necrosis Factor Receptor Activity Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Adhesion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Exocyst Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Locomotion Cellular Response To Interleukin-4 Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granulocyte Chemotaxis CCR Chemokine Receptor Binding Response To Interleukin-4 Positive Regulation Of T Cell Cytokine Production	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Ubiquitin-protein Transferase Activity Alcohol Dehydrogenase (NADP+) Activity Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Ubiquitin Protein Ligase Activity Cytoplasm Cytokine-mediated Signaling Pathway Lymphocyte Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immune System Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Toll-like Receptor Signaling Pathway Leukocyte Activation Regulation Of Adaptive Immune Response Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity TORC2 Complex Disassembly Pinceau Fiber MWP Complex Positive Regulation Of Type I Hypersensitivity Cell Activation B Cell Affinity Maturation 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Ubiquitin Protein Ligase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Immunoglobulin Production Zinc Ion Binding PDZ Domain Binding Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Interferon Production
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