TNFSF18

Description		TNF superfamily member 18
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Migration Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 27182965 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 22057235 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)
Novel Interacting Genes		1 novel interacting genes: XCL1
Interacting Genes		2 interacting genes: EXOC3L2 TNFRSF18
Entrez ID		8995
HPRD ID		04874
Ensembl ID		ENSG00000120337
Uniprot IDs		A0A0U5JXL4 Q9UNG2
PDB IDs		2Q1M 2R30 2R32 3B93 3B94 7KHD 7LAW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Leukocyte Migration Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Tumor Necrosis Factor Receptor Activity Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Adhesion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Exocyst Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Locomotion Cellular Response To Interleukin-4 Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granulocyte Chemotaxis CCR Chemokine Receptor Binding Response To Interleukin-4 Positive Regulation Of T Cell Cytokine Production
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