RHOT2 and TMEM86B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHOT2	TMEM86B
Description		ras homolog family member T2	transmembrane protein 86B
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity GDP Binding Metal Ion Binding	Protein Binding Hydrolase Activity Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity D-lysine 5,6-aminomutase Activity
	Biological Process	Mitochondrion Organization Cellular Homeostasis Mitochondrion Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization	Lipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process
Pathways		RHOT2 GTPase cycle RHOT2 GTPase cycle	Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Red blood cell traits ( 23446634)	Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469 33536424)
Interacting Genes		5 interacting genes: PRKN SAR1A TMEM14B TMEM86B ZFYVE9	106 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FFAR2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22
Entrez ID		89941	255043
HPRD ID		15248	14540
Ensembl ID		ENSG00000140983	ENSG00000180089
Uniprot IDs		A0A8V8TM48 Q8IXI1	Q8N661
PDB IDs		5KUT
Enriched GO Terms of Interacting Partners?		Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Amino Acid Sensor Activity D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Vesicle Transport Regulation Of COPII Vesicle Coating Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi Identical Protein Binding Response To Dopamine Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To L-glutamate Inclusion Body Assembly Cellular Response To Manganese Ion	Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding Membrane Fusion Mitochondrial Membrane Endomembrane System Plasma Membrane Organelle Localization By Membrane Tethering Membrane Organization Cellular Localization Vesicle Membrane Docking Vesicle Fusion Vesicle Docking Organelle Membrane Fusion SNARE Binding Golgi Vesicle Transport C-4 Methylsterol Oxidase Activity Sterol Biosynthetic Process Vesicle Organization Organelle Fusion Connexin Complex B Cell Receptor Complex Gap Junction Channel Activity Nuclear Inner Membrane Localization Within Membrane Gap Junction
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