RHOT2

Name	ras homolog family member T2
Structure
Novel Interactors	2 novel interactors: DNAL4 GLIS2
Interactors	5 interactors: PRKN SAR1A TMEM14B TMEM86B ZFYVE9
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity GDP Binding Metal Ion Binding
	Biological Process	Mitochondrion Organization Cellular Homeostasis Mitochondrion Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization
Pathways	RHOT2 GTPase cycle RHOT2 GTPase cycle
GWAS	Body mass index ( 26426971 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Hip circumference adjusted for BMI ( 34021172 ) Red blood cell traits ( 23446634 )
Entrez ID	89941
HPRD ID	15248
Ensembl ID	ENSG00000140983
Uniprot IDs	A0A8V8TM48 Q8IXI1
PDB IDs	5KUT
GO Terms Enriched among Interactors ?	Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Amino Acid Sensor Activity D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Vesicle Transport Regulation Of COPII Vesicle Coating Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi Identical Protein Binding Response To Dopamine Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To L-glutamate Inclusion Body Assembly Cellular Response To Manganese Ion