RHOT2 and DNAL4

		RHOT2	DNAL4
Description		ras homolog family member T2	dynein axonemal light chain 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity GDP Binding Metal Ion Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Mitochondrion Organization Cellular Homeostasis Mitochondrion Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization	Microtubule-based Process Microtubule-based Movement
Pathways		RHOT2 GTPase cycle RHOT2 GTPase cycle	Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Red blood cell traits ( 23446634)
Interacting Genes		5 interacting genes: PRKN SAR1A TMEM14B TMEM86B ZFYVE9	14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54
Entrez ID		89941	10126
HPRD ID		15248	13239
Ensembl ID		ENSG00000140983	ENSG00000100246
Uniprot IDs		A0A8V8TM48 Q8IXI1	O96015
PDB IDs		5KUT
Enriched GO Terms of Interacting Partners?		Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Amino Acid Sensor Activity D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Vesicle Transport Regulation Of COPII Vesicle Coating Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi Identical Protein Binding Response To Dopamine Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To L-glutamate Inclusion Body Assembly Cellular Response To Manganese Ion
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