ARID5B and RIOX2

		ARID5B	RIOX2
Description		AT-rich interaction domain 5B	ribosomal oxygenase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding	Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Peptidyl-histidine Dioxygenase Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor	Chromatin Remodeling Ribosome Biogenesis Negative Regulation Of DNA-templated Transcription
Pathways		HDMs demethylate histones	HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 29348612 33891562 28817678 25310577 23512250) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 30894546 29760442) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454 29617998) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 27863252 32888494) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 22446963 23143596 24390342 30423114 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum metabolite levels ( 33031748) Serum total protein levels ( 23022100) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 26502338 27399966 33272962 23273568) Tinnitus ( 33742053) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 32499647) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: RUNX1	5 interacting genes: APP H3C3 LNX1 MYC OGT
Entrez ID		84159	84864
HPRD ID		18880	17575
Ensembl ID		ENSG00000150347	ENSG00000170854
Uniprot IDs		Q14865	A0A6M8YDW1 Q8IUF8
PDB IDs		1IG6 2OEH	2XDV 4BU2 4BXF
Enriched GO Terms of Interacting Partners?			Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Chromatin Organization Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein-containing Complex Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Stem Cell Population Maintenance Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Negative Regulation Of DNA-templated Transcription Response To Peptide Response To Cytokine Lipoprotein Particle Intracellular Chemical Homeostasis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy NK T Cell Proliferation Myc-Max Complex Regulation Of Acinar Cell Proliferation Skeletal System Morphogenesis Protein O-acetylglucosaminyltransferase Activity Receptor Localization To Non-motile Cilium Protein-containing Complex Organization Negative Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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