ARID5B

Description		AT-rich interaction domain 5B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor
Pathways		HDMs demethylate histones
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 29348612 33891562 28817678 25310577 23512250) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 30894546 29760442) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454 29617998) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 27863252 32888494) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 22446963 23143596 24390342 30423114 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum metabolite levels ( 33031748) Serum total protein levels ( 23022100) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 26502338 27399966 33272962 23273568) Tinnitus ( 33742053) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 32499647) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		9 novel interacting genes: ANXA7 CAMK2G CCND2 LZTS1 NRBF2 RHOBTB1 RIOX2 SLC22A1 USP54
Interacting Genes		1 interacting genes: RUNX1
Entrez ID		84159
HPRD ID		18880
Ensembl ID		ENSG00000150347
Uniprot IDs		Q14865
PDB IDs		1IG6 2OEH
Enriched GO Terms of Interacting Partners?
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