CDC123 and USP9X

Number of citations: 0 (PubMedID 37314216)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		CDC123	USP9X
Name		cell division cycle 123	ubiquitin specific peptidase 9 X-linked
Structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Protein Folding Chaperone Metal Ion Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Protein Folding Eukaryotic Translation Initiation Factor 2 Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation
Pathways		None	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
GWAS		Body fat percentage and type 2 diabetes (pairwise) ( 33619380 ) Body mass index ( 28892062 ) Childhood onset type 2 diabetes ( 33479058 ) Chronic obstructive pulmonary disease ( 30804561 ) Circulating leptin levels or type 2 diabetes ( 32341051 ) Coronary artery disease ( 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) FEV1 ( 30804560 ) Glycated hemoglobin levels ( 34059833 ) Hemoglobin A1c levels ( 29403010 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 28166213 30804560 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011 ) Myocardial infarction ( 33532862 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Type 2 diabetes ( 29358691 32499647 31118516 30718926 30297969 30054458 18372903 28869590 26961502 26818947 24509480 22961080 22885922 20862305 )	Migraine ( 27322543 )
Novel Interactors		1 novel interactors: ARID1A	1 novel interactors: RPGR
Interacting Genes		3 interacting genes: HRAS USP9X ZNF512B	32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL
Entrez ID		8872	8239
HPRD ID		12586	02091
Ensembl ID		ENSG00000151465	ENSG00000124486
Uniprot IDs		O75794	A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008
PDB IDs		8PHD 8PHV	5VBD 5WCH 7YXX 7YXY
GO Terms Enriched among Interactors		None	Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration