DDX49 and MIR1-2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		DDX49	MIR1-2
Description		DEAD-box helicase 49	microRNA 1-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	RISC Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	RRNA Processing Positive Regulation Of Cell Growth Regulation Of RRNA Stability	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872)
Interacting Genes		12 interacting genes: APP CEBPA HAP1 MIR1-2 MIR138-2 MIR140 MIR15A MIR199A1 MIR214 PAGE1 PSMB2 STX1A	78 interacting genes: ADARB1 APOBEC3B C1QBP CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FUS GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM71 UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		54555	406905
HPRD ID		10864
Ensembl ID		ENSG00000105671	ENSG00000284453
Uniprot IDs		Q9Y6V7
PDB IDs
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Cell Population Proliferation Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Biosynthetic Process Regulation Of Chemokine Production Regulation Of Connective Tissue Replacement Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Migration Regulation Of BMP Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Tissue Remodeling Positive Regulation Of Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Myosin Binding Negative Regulation Of Amyloid-beta Formation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of SMAD Protein Signal Transduction	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Nucleus Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Processing Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process P-body Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Nucleolus MRNA Stabilization Regulation Of Metabolic Process Positive Regulation Of Gene Expression TRNA Metabolic Process Negative Regulation Of Metabolic Process
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