DDX49 and MIR138-2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		DDX49	MIR138-2
Description		DEAD-box helicase 49	microRNA 138-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	RISC Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	RRNA Processing Positive Regulation Of Cell Growth Regulation Of RRNA Stability	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872)
Interacting Genes		12 interacting genes: APP CEBPA HAP1 MIR1-2 MIR138-2 MIR140 MIR15A MIR199A1 MIR214 PAGE1 PSMB2 STX1A	87 interacting genes: AIMP1 AIMP2 APOBEC3B C1QBP CELF1 CPSF1 CPSF6 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUFIP2 PATL1 PDCD11 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM26 TUT7 U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF106
Entrez ID		54555	406930
HPRD ID		10864
Ensembl ID		ENSG00000105671	ENSG00000207649
Uniprot IDs		Q9Y6V7
PDB IDs
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Cell Population Proliferation Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Biosynthetic Process Regulation Of Chemokine Production Regulation Of Connective Tissue Replacement Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Migration Regulation Of BMP Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Tissue Remodeling Positive Regulation Of Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Myosin Binding Negative Regulation Of Amyloid-beta Formation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of SMAD Protein Signal Transduction	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process Nucleolus TRNA Aminoacylation MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Positive Regulation Of Cytoplasmic Translation Ligase Activity Regulation Of Metabolic Process CRD-mediated MRNA Stabilization P-body
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