UNC5C and DAPK1

Number of citations of the paper that reports this interaction (PMID 15729359)
28

Data Source:
HPRD (in vivo)

		UNC5C	DAPK1
Gene Name		unc-5 homolog C (C. elegans)	death-associated protein kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Actin Cytoskeleton
	Molecular Function	Netrin Receptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Syntaxin-1 Binding Identical Protein Binding
	Biological Process	Apoptotic Process Axon Guidance Brain Development Regulation Of Cell Migration Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process	Protein Phosphorylation Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Autophosphorylation Cellular Response To Interferon-gamma Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways		Axon guidance Netrin mediated repulsion signals Netrin-1 signaling	Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs			5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
Diseases
GWAS		Obesity-related traits ( 23251661) P-tau181p ( 20932310)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Response to gemcitabine in pancreatic cancer ( 22293537)
Protein-Protein Interactions		2 interactors: DAPK1 NTN1	16 interactors: CALM1 FADD IKBKG LNX1 MAPK1 MAPK3 MDM2 MIB1 MYL12B STX1A TNFRSF1A TRADD UNC5A UNC5B UNC5C YWHAB
Entrez ID		8633	1612
HPRD ID		04678	02902
Ensembl ID		ENSG00000182168	ENSG00000196730
Uniprot IDs		A8K385 O95185	P53355 Q59H88
PDB IDs			1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L
Enriched GO Terms of Interacting Partners?			Apoptotic Process Programmed Cell Death Cell Death Death Response To External Stimulus Axon Guidance Anterior/posterior Axon Guidance Fc-epsilon Receptor Signaling Pathway Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Axonogenesis Cell Surface Receptor Signaling Pathway Axon Development Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Chemotaxis Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Cell Morphogenesis Involved In Differentiation Toll-like Receptor 4 Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Intracellular Transport Neurotrophin Signaling Pathway Regulation Of Signaling Innate Immune Response Regulation Of Intracellular Signal Transduction Neuron Projection Development Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis
Tagcloud ?		ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain upa zonula zu5	aberrant aifm2 aml array backgroundpediatric bgs bisulfite comprises conclusionin dcc details dysregulated ebf3 firstly glioblastoma hypermethylated idiopathic itp kaplan leukemogenesis meier methodstwelve methylated msp nbm patterning pediatric purpura thrombocytopenic
Tagcloud (Difference) ?		ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain upa zonula zu5	aberrant aifm2 aml array backgroundpediatric bgs bisulfite comprises conclusionin dcc details dysregulated ebf3 firstly glioblastoma hypermethylated idiopathic itp kaplan leukemogenesis meier methodstwelve methylated msp nbm patterning pediatric purpura thrombocytopenic
Tagcloud (Intersection) ?