PLPP1 and FAHD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PLPP1	FAHD1
Description		phospholipid phosphatase 1	fumarylacetoacetate hydrolase domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Caveola Membrane Apical Plasma Membrane Membrane Raft Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity	Catalytic Activity Protein Binding Oxaloacetate Decarboxylase Activity Hydrolase Activity Lyase Activity Isomerase Activity Acetylpyruvate Hydrolase Activity Fumarylpyruvate Hydrolase Activity Metal Ion Binding Acylpyruvate Hydrolase Activity Oxaloacetate Tautomerase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Catabolic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Phospholipid Dephosphorylation	Oxaloacetate Metabolic Process Carboxylic Acid Metabolic Process
Pathways		Sphingolipid catabolism	Pyruvate metabolism
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		5 interacting genes: CREB3 FAHD1 FXYD1 GPR42 SSMEM1	4 interacting genes: BNIP2 EXOSC4 PAXIP1 PLPP1
Entrez ID		8611	81889
HPRD ID		06178	13286
Ensembl ID		ENSG00000067113	ENSG00000180185
Uniprot IDs		O14494	Q6P587
PDB IDs			1SAW 6FOG 6FOH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Glutathionylation Positive Regulation Of Deacetylase Activity Fumarylpyruvate Hydrolase Activity Oxaloacetate Tautomerase Activity Acylpyruvate Hydrolase Activity Acetylpyruvate Hydrolase Activity Positive Regulation Of Monoatomic Ion Transport Oxaloacetate Decarboxylase Activity Release From Viral Latency Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Cardiac Muscle Cell Membrane Potential CCR1 Chemokine Receptor Binding Oxaloacetate Metabolic Process CAMP Response Element Binding Protein Binding Sodium:potassium-exchanging ATPase Complex Regulation Of Metal Ion Transport Induction Of Positive Chemotaxis	Spindle Pole Centrosome Response To Oxygen-glucose Deprivation Ceramide-1-phosphate Phosphatase Activity Diacylglycerol Diphosphate Phosphatase Activity Lipid Phosphatase Activity Phosphatidate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity MLL3/4 Complex Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Chorion Development Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Histone MRNA Catabolic Process Exosome (RNase Complex) Exoribonuclease Complex Nuclear Exosome (RNase Complex) RNA Exonuclease Activity Sno(s)RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Sphingosine Metabolic Process Maturation Of 5.8S RRNA Androgen Receptor Signaling Pathway SnRNA 3'-end Processing Histone MRNA Metabolic Process Diol Metabolic Process Histone Methyltransferase Complex Positive Regulation Of Isotype Switching MRNA 3'-UTR AU-rich Region Binding DNA Modification Blastocyst Development
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