LGR5 and REEP5

Data Source: HiPPIP (Novel)

		LGR5	REEP5
Name		leucine rich repeat containing G protein-coupled receptor 5	receptor accessory protein 5
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Trans-Golgi Network Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein-hormone Receptor Activity	Protein Binding
	Biological Process	Hair Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Oocyte Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Population Proliferation Inner Ear Development Positive Regulation Of Canonical Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Endoplasmic Reticulum Membrane Organization
Pathways		Regulation of FZD by ubiquitination	None
GWAS		Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Type 2 diabetes ( 18372903 20581827 22885922 29358691 30297969 32499647 )	Attention deficit hyperactivity disorder ( 18839057 ) Daytime nap ( 33568662 ) Reaction time ( 29844566 )
Interacting Genes		None recorded	13 interacting genes: ABHD4 ARFGAP1 ARFIP2 CHRM5 GTF2H1 NUDT3 PBX3 PITPNC1 RAB5B RABAC1 RGS2 SNX1 VKORC1
Entrez ID		8549	7905
HPRD ID		05979	15918
Ensembl ID		ENSG00000139292	ENSG00000129625
Uniprot IDs		A0A0A8K8C7 O75473	Q00765
PDB IDs		4BSR 4BSS 4BST 4BSU 4KNG 4UFR 4UFS	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Membrane Organization Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Sarcoplasmic Reticulum	None