PIR and BCL3

Number of citations of the paper that reports this interaction (PMID 10362352)
64

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		PIR	BCL3
Gene Name		pirin (iron-binding nuclear protein)	B-cell CLL/lymphoma 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Protein Complex Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cofactor Activity Protein Binding Quercetin 2,3-dioxygenase Activity Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Monocyte Differentiation Oxidation-reduction Process	Protein Import Into Nucleus, Translocation Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Transcription, DNA-templated Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Response To UV-C Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Interferon-gamma Production T-helper 1 Type Immune Response Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Interleukin-10 Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 23565137)
Protein-Protein Interactions		4 interactors: BCL3 NFIX NFKBIA SMAD9	31 interactors: BARD1 COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK3 MAPRE1 N4BP2 NCOA1 NCOA6 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP
Entrez ID		8544	602
HPRD ID		04510	00179
Ensembl ID		ENSG00000087842	ENSG00000069399
Uniprot IDs		O00625	P20749
PDB IDs		1J1L 3ACL 4ERO 4EWA 4EWD 4EWE 4GUL 4HLT	1K1A 1K1B
Enriched GO Terms of Interacting Partners?		Protein Import Into Nucleus, Translocation Positive Regulation Of Transcription, DNA-templated Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Cellular Metabolic Process Protein Import Into Nucleus Nuclear Import Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Protein Import Regulation Of Protein Import Into Nucleus Protein Localization To Nucleus Hindbrain Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Interleukin-10 Biosynthetic Process Response To Abiotic Stimulus Regulation Of Protein Localization To Nucleus Positive Regulation Of Metabolic Process Regulation Of Nucleocytoplasmic Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Follicular Dendritic Cell Differentiation T-helper 2 Cell Differentiation Regulation Of Binding Regulation Of Intracellular Protein Transport Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Marginal Zone B Cell Differentiation Cytoplasmic Sequestering Of NF-kappaB Cellular Response To Cold Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Mullerian Duct Regression Establishment Of Protein Localization To Organelle Regulation Of RNA Metabolic Process Positive Regulation Of Cytokine Production Type 2 Immune Response Protein Targeting Intracellular Signal Transduction Regulation Of Gene Expression	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Viral Process Response To Growth Factor Response To Organic Substance Cellular Response To Organic Substance Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway DNA-templated Transcription, Initiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Histone Modification Cellular Response To Stress Fc Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		125i alpha2 blast cleave columns conditioned dependently digest facilitating film gccm genbank germ homogeneity hydrolyzing intertesticular junction kda kyefyeixll macroglobulin nh2 postulated protease proteolysis secretory sertoli testes testin tryptic	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		125i alpha2 blast cleave columns conditioned dependently digest facilitating film gccm genbank germ homogeneity hydrolyzing intertesticular junction kda kyefyeixll macroglobulin nh2 postulated protease proteolysis secretory sertoli testes testin tryptic	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?