PAQR8 and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PAQR8	EHHADH
Description		progestin and adipoQ receptor family member 8	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Oogenesis Response To Steroid Hormone	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways			Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases
GWAS		Atopic march ( 26542096) Platelet count ( 27863252 32888494)	Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		3 interacting genes: EHHADH LEPROTL1 MPP1	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		85315	1962
HPRD ID		07415	06125
Ensembl ID		ENSG00000170915	ENSG00000113790
Uniprot IDs		B3KXW6 Q8TEZ7	Q08426
PDB IDs
Enriched GO Terms of Interacting Partners?		Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Enoyl-CoA Hydratase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity GMP Kinase Activity Negative Regulation Of Growth Hormone Receptor Signaling Pathway Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase GDP Metabolic Process Regulation Of Growth Hormone Receptor Signaling Pathway Alpha-linolenic Acid Metabolic Process NAD+ Binding Cortical Cytoskeleton GMP Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Long-chain Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Stereocilium Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Peroxisomal Matrix Fatty Acid Beta-oxidation Fatty Acid Derivative Biosynthetic Process Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Regulation Of Granulocyte Chemotaxis Multivesicular Body Sorting Pathway Fatty Acid Catabolic Process Fatty Acid Derivative Metabolic Process Fatty Acid Oxidation Nucleoside Monophosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Lipid Oxidation	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
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