PPIL4 and RBFOX2

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		PPIL4	RBFOX2
Name		peptidylprolyl isomerase like 4	RNA binding fox-1 homolog 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	None	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Metabolic Process Estrogen Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription
Pathways		mRNA Splicing - Major Pathway	FGFR2 alternative splicing
GWAS		Brain morphology (MOSTest) ( 32665545 ) Rheumatoid arthritis ( 24390342 30423114 ) Subcortical volume (MOSTest) ( 32665545 )	Body size at age 10 ( 32376654 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Reading disability or specific language impairment (pleiotropy) ( 25065397 ) Red cell distribution width ( 32888494 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		5 interacting genes: CHERP DLG2 PAX6 RBFOX2 SMAD5	182 interacting genes: ADARB1 ALG13 ANKHD1 APH1A ATN1 ATXN1 ATXN1L BAG4 BOLL C1orf94 CALD1 CAMK2A CAMK2B CHAF1A CHERP CLASP2 CPSF7 DAB1 DAZAP2 DDX21 DDX5 DEDD2 DENND1B DMRTB1 EIF4ENIF1 ELAVL1 ELAVL2 ESR1 ESR2 FAM168B FBXO7 FSAF1 GIMAP4 GLIS2 GTF2A1L H1-4 HMGA1 HNRNPAB HNRNPF HNRNPH1 HNRNPH2 HNRNPK KHDRBS1 KHDRBS2 KIF20A KRT31 KRTAP6-2 LMNA LSM5 MAGED1 MAPK1IP1L MBNL1 MED7 MIR1-1 MIR106A MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR9-1 MIR9-2 MIR9-3 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL4 MSI2 MTG1 MYO1C NAF1 NLGN3 NOL8 NR2E3 NXF1 OGT OXER1 PA2G4 PCBP1 PCBP2 PCNP PDIA3 PEG10 POLR3D PPIL4 PRMT5 PRPF19 PRPF38B PRRC2B PSMA3 PSMF1 PTBP1 PURB QARS1 QKI RBFOX1 RBFOX3 RBM12 RBM17 RBM22 RBM23 RBM42 RBPMS RBPMS2 RERE RHOXF2 RNF8 RPL3 RPL4 RPN1 RPS13 RPS28 SDHC SF1 SF3A1 SF3B3 SF3B4 SMN1 SNRPA SNRPC SNW1 SPATS2L SPMIP9 SPOP SRP68 ST13 SUPV3L1 SURF6 TNRC6A TOLLIP U2AF2 UBQLN2 VAC14 YTHDF1 YTHDF3 ZC3H10 ZNF137P
Entrez ID		85313	23543
HPRD ID		07606	15231
Ensembl ID		ENSG00000131013	ENSG00000100320
Uniprot IDs		Q8WUA2	A0A8Q3WKT3 O43251
PDB IDs		7QTT 8CH6 8I0S 8I0T 8I0U 8I0V	2CQ3
GO Terms Enriched among Interactors		Nervous System Development System Development Forebrain-midbrain Boundary Formation Pancreatic A Cell Development GMP Kinase Activity Retrograde Axonal Protein Transport Anterograde Axonal Protein Transport Developmental Process Regulation Of Fas Signaling Pathway Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Fas Signaling Pathway Mullerian Duct Regression Osteoblast Fate Commitment Chemical Homeostasis Cell Fate Commitment SMAD Protein Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DEAD/H-box RNA Helicase Binding Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Type B Pancreatic Cell Differentiation Forebrain Neuron Fate Commitment Habenula Development Oligodendrocyte Cell Fate Specification Ventral Spinal Cord Development Pallium Development Formation Of Anatomical Boundary Iris Morphogenesis Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Juxtaparanode Region Of Axon GDP Metabolic Process Cellular Response To Potassium Ion Protein Transport Along Microtubule Negative Regulation Of DNA-templated Transcription Anatomical Structure Regression Ubiquitin Protein Ligase Binding Homeostatic Process Negative Regulation Of RNA Biosynthetic Process Dorsal/ventral Axis Specification HMG Box Domain Binding Co-SMAD Binding Regulation Of Timing Of Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Regulation Of Development, Heterochronic	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process RNA Binding Extracellular Vesicle Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Translation Nucleic Acid Binding Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of RNA Splicing MRNA Binding Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Primary Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process RNA Processing Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development