CNPY4 and AIFM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNPY4	AIFM2
Description		canopy FGF signaling regulator 4	AIF family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	DNA Binding Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Flavin Adenine Dinucleotide Binding
	Biological Process	Positive Regulation Of Protein Localization To Plasma Membrane	Ubiquinone Metabolic Process Apoptotic Mitochondrial Changes Respiratory Electron Transport Chain Vitamin K Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress Cellular Detoxification
Pathways			TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Refractive error ( 32231278) Renal overload gout ( 32238385) Subcortical volume (MOSTest) ( 32665545)	Post bronchodilator FEV1/FVC ratio ( 26634245) Rheumatoid arthritis ( 30891314)
Interacting Genes		3 interacting genes: AIFM2 ARL4D TLR4	3 interacting genes: CNPY4 PLXNB2 TRIM21
Entrez ID		245812	84883
HPRD ID		14611	09797
Ensembl ID		ENSG00000166997	ENSG00000042286
Uniprot IDs		Q8N129	Q9BRQ8
PDB IDs			8JSC 8WIK 8YO8 8YOQ 8YOX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Detection Of Fungus Nitric Oxide Production Involved In Inflammatory Response Wound Healing Involved In Inflammatory Response MHC Class II Biosynthetic Process Electron-transferring-flavoprotein Dehydrogenase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Positive Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-23 Production Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Cellular Response To Lipoteichoic Acid Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Programmed Cell Death Detection Of Molecule Of Bacterial Origin Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Platelet Activation Intestinal Epithelial Structure Maintenance Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Lipopolysaccharide Receptor Complex MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopolysaccharide Immune Receptor Activity Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Detection Of Lipopolysaccharide Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process NK T Cell Activation Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Cellular Response To Stress B Cell Proliferation Involved In Immune Response Positive Regulation Of Stress-activated MAPK Cascade Astrocyte Development Microglia Differentiation T-helper 1 Type Immune Response Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Ubiquinone Metabolic Process Regulation Of Ferroptosis Vitamin K Metabolic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress	Regulation Of Protein Deubiquitination Stress Granule Disassembly Positive Regulation Of Protein Binding Negative Regulation Of Protein Deubiquitination TRNA Stabilization Excitatory Synapse Assembly Negative Regulation Of Translation In Response To Stress Positive Regulation Of Viral Entry Into Host Cell Suppression Of Viral Release By Host Protein K27-linked Ubiquitination Negative Regulation Of Viral Transcription Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Translation In Response To Stress
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