RBM38 and HNRNPH1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBM38	HNRNPH1
Description		RNA binding motif protein 38	heterogeneous nuclear ribonucleoprotein H1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding
	Biological Process	MRNA Processing Negative Regulation Of Cell Population Proliferation RNA Splicing Regulation Of Myotube Differentiation Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of RNA Splicing Regulation Of Cell Cycle 3'-UTR-mediated MRNA Stabilization	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Regulation Of RNA Splicing
Pathways			FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs			Copper
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycated hemoglobin levels ( 34059833) Haemorrhoidal disease ( 33888516) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 29403010 28017375) Mean corpuscular volume ( 28017375 28453575 20139978 29403010) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Red blood cell traits ( 23222517) Response to statin therapy ( 20339536) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 23300278)	Daytime sleep phenotypes ( 27126917) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		4 interacting genes: HNRNPH1 MDM2 RCHY1 ZC3H10	136 interacting genes: APBB1 ARHGEF16 CASP7 CATSPER1 CCDC120 CCNK CRMP1 DDX17 DUX4 DZIP3 ENKD1 ERG FOXP1 GPANK1 GPS2 HIPK3 HNRNPF HNRNPH3 HNRNPM KHSRP KRTAP13-2 LMO1 LMO3 LNX1 MAGED1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL53 MSI2 MTNR1A MYPOP NCBP1 NCBP2 NDRG1 NFKBID NUDT16L1 OGT OXER1 PATZ1 PCAT1 PEX5 PIN1 POLR1C RALY RAMAC RBFOX2 RBM38 RNF10 RNF4 SAXO4 SF1 SF3B4 SNRPB SNRPC SPG21 SREK1 SUMO2 SUMO4 TCERG1 TEKT3 TEKT4 TOM1L1 WEE2-AS1 YPEL3 YWHAG YWHAQ
Entrez ID		55544	3187
HPRD ID		15268	03021
Ensembl ID		ENSG00000132819	ENSG00000169045
Uniprot IDs		Q9H0Z9	A0A384MEJ3 A0A9L9PY23 A0AAG2UWX3 E9PCY7 G8JLB6 H0YBD7 P31943
PDB IDs		2CQD 6JVX 6JVY	2LXU 6DHS 7ZUG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process P53 Binding Response To Formaldehyde Protein Autoubiquitination Ubiquitin Binding Cellular Response To Vitamin B1 Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Splicing Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Vitamin B1 NEDD8 Ligase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Actinomycin D Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Water-immersion Restraint Stress Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To Actinomycin D Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To UV-C Error-free Translesion Synthesis Receptor Serine/threonine Kinase Binding Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Ubiquitin-protein Transferase Activity Negative Regulation Of MiRNA Processing Atrial Septum Development Fibroblast Activation Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic 5S RRNA Binding Regulation Of Proteolysis Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To UV-C Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing Cellular Response To Estrogen Stimulus Response To Magnesium Ion RNA Binding Poly(U) RNA Binding Nucleus SUMO Transferase Activity Endocardial Cushion Morphogenesis Response To Ether	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility
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