KMT5C and H4C7

Number of citations of the paper that reports this interaction (PubMedID 35907431)
0

Data Source:
BioGRID (enzymatic study)

		KMT5C	H4C7
Description		lysine methyltransferase 5C	H4 clustered histone 7
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin	Nucleosome Nucleus Chromosome
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Transferase Activity Histone Binding Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity S-adenosyl-L-methionine Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling Methylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: H4C1 H4C7 RB1 RBL1 RBL2	13 interacting genes: AGTRAP APOC1 CIDEB EP300 FGF14 FKBP7 KAT2A KAT8 KMT5B KMT5C MAIP1 RHBDD2 TMED8
Entrez ID		84787	8369
HPRD ID		15454	11806
Ensembl ID		ENSG00000133247	ENSG00000275663
Uniprot IDs		A0A0D9SF94 Q86Y97	Q99525
PDB IDs		3RQ4
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Chromatin Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Protein Localization To Chromosome, Centromeric Region Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Phosphorylation Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding Regulation Of Mitotic Cell Cycle Structural Constituent Of Chromatin Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Protein Localization To Chromosome Nucleosome Assembly Nucleosome Chromatin Remodeling Chromosome Nucleosome Organization Regulation Of Cell Cycle Process Chromatin Lock Complex DNA Binding Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Collagen Fibril Organization Protein-DNA Complex Assembly Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Enucleate Erythrocyte Differentiation Regulation Of Cell Cycle Chromatin Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Gene Expression Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding	Histone Acetyltransferase Complex Protein Propionyltransferase Activity Protein-lysine-acetyltransferase Activity Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone Acetyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Very-low-density Lipoprotein Particle Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Small Molecule Metabolic Process Chromatin Remodeling Condensed Chromosome, Centromeric Region Negative Regulation Of Gluconeogenesis Chromosome Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains S-adenosyl-L-methionine Binding Positive Regulation Of Adaptive Immune Response Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Acyltransferase Activity Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Protein Acetylation DNA-binding Transcription Factor Binding Chromatin Binding Regulation Of Isotype Switching Regulation Of Triglyceride Metabolic Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Somitogenesis Peptidyl-lysine Propionylation Segmentation Regulation Of Lymphocyte Activation Swimming Histone Lactyltransferase (CoA-dependent) Activity Gluconeogenesis Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity
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