KMT5C

Description		lysine methyltransferase 5C
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GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Transferase Activity Histone Binding Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling Methylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: H4C1 H4C7 RB1 RBL1 RBL2
Entrez ID		84787
HPRD ID		15454
Ensembl ID		ENSG00000133247
Uniprot IDs		A0A0D9SF94 Q86Y97
PDB IDs		3RQ4
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Chromatin Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Protein Localization To Chromosome, Centromeric Region Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Phosphorylation Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding Regulation Of Mitotic Cell Cycle Structural Constituent Of Chromatin Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Protein Localization To Chromosome Nucleosome Assembly Nucleosome Chromatin Remodeling Chromosome Nucleosome Organization Regulation Of Cell Cycle Process Chromatin Lock Complex DNA Binding Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Collagen Fibril Organization Protein-DNA Complex Assembly Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Enucleate Erythrocyte Differentiation Regulation Of Cell Cycle Chromatin Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Gene Expression Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding
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