ASB7

Description		ankyrin repeat and SOCS box containing 7
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Protein Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Chin dimples ( 27182965) Chronotype ( 30696823) Lower body strength ( 27325353) Morning person ( 30696823) Optic cup area ( 25631615 28073927 31798171) Optic disc area ( 28073927) Response to taxane treatment (paclitaxel) ( 23006423) Vertical cup-disc ratio ( 28073927 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Novel Interacting Genes		1 novel interacting genes: DYNC1H1
Interacting Genes		3 interacting genes: ATF4 CDK2 PSRC1
Entrez ID		140460
HPRD ID		10674
Ensembl ID		ENSG00000183475
Uniprot IDs		Q9H672
PDB IDs		8Y1U
Enriched GO Terms of Interacting Partners?		Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Cell Division Positive Regulation Of Organelle Organization Regulation Of Mitotic Spindle Organization Organelle Organization Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Regulation Of Cold-induced Thermogenesis Centrosome CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Chromatin Organization Regulation Of Cell Cycle Process Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process X Chromosome Regulation Of Cell Cycle Transcription Regulator Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Regulation Of Microtubule-based Process Positive Regulation Of Metabolic Process Lens Fiber Cell Morphogenesis Protection From Non-homologous End Joining At Telomere Membraneless Organelle Assembly HRI-mediated Signaling Positive Regulation Of Spindle Assembly Regulation Of Phosphate Transport Cellular Response To Manganese Ion Regulation Of Heterochromatin Formation Mitochondrial Respirasome Assembly
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