HES7 and PIH1D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HES7	PIH1D2
Description		hes family bHLH transcription factor 7	PIH1 domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm R2TP Complex Protein Folding Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Anterior/posterior Pattern Specification Post-anal Tail Morphogenesis Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	Box C/D SnoRNP Assembly RRNA Processing Protein Stabilization
Pathways		Somitogenesis
Drugs
Diseases		Spondylocostal dysostosis (SCD)
GWAS		Height ( 25282103)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: OSTF1 PIH1D2 PRPF31 QARS1 TCEA2 TCEANC	69 interacting genes: ANKRD11 BAG3 BANP CBLL2 CBX8 CCNL2 CDC23 CDCA8 CDKL3 CFAP206 COMMD3 CT55 CTAG1A CTAG1B DES DPH3 DSCAM EIF4A2 EXOSC5 FRS3 GFAP GMCL1 GPRASP2 HES7 HSF4 IGF2BP3 IQUB ITGB3BP KRTAP12-2 KRTAP12-4 LAP3 LMNB1 MCCD1 MDFI MED20 MISP MRFAP1L1 MVP NFIL3 NHSL2 NOTO NTAQ1 NXF1 PBX4 PLEKHJ1 POLR1C PRDM6 PRMT3 RALA REL RSPO4 SDCBP SERTAD1 SLPI SPRED1 SSX3 SUOX TAF6 TASOR2 TBATA TCEA2 TNNI1 TTC23 ZBTB1 ZMAT5 ZNF185 ZNF417 ZNF438 ZNF688
Entrez ID		84667	120379
HPRD ID		09729	14021
Ensembl ID		ENSG00000179111	ENSG00000150773
Uniprot IDs		Q9BYE0	Q8WWB5
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Localization Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation U4atac SnRNP SnRNP Binding U4atac SnRNA Binding SnoRNA Localization Protein-RNA Complex Assembly Spliceosomal Tri-snRNP Complex R2TP Complex U4 SnRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade U4 SnRNP Box C/D SnoRNP Assembly Spliceosomal Tri-snRNP Complex Assembly Precatalytic Spliceosome Ribonucleoprotein Complex Transcription Elongation Factor Complex	Protein Binding Nucleus
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