SPZ1 and DTNB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SPZ1	DTNB
Description		spermatogenic leucine zipper 1	dystrobrevin beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Synapse Inhibitory Synapse Postsynapse
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription	Neuron Differentiation Synaptic Signaling
Pathways			Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases
GWAS			A body shape index ( 34021172) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cutaneous malignant melanoma ( 32341527) Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Height ( 18391951) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) LDL cholesterol ( 21347282) Macular thickness ( 30535121) Multiple myeloma ( 26007630 22120009 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Nevus count or cutaneous melanoma ( 32341527) Resistant hypertension ( 31545351) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Working memory ( 31598132)
Interacting Genes		5 interacting genes: APP DTNB HOXB9 KDM1A VHL	61 interacting genes: ABI1 ABI2 ABI3 AMOTL2 BEGAIN CBY2 CCDC136 CCDC196 CCDC85B CCDC88B CCHCR1 CEP55 CEP63 CTBP2 DEUP1 DMD DTNBP1 FAM167A FSD2 GGA1 HMG20A KIF5A KIF5B KRT15 KRT27 KRT31 KRT33B KRT35 KRT38 KRT40 LURAP1 MB21D2 MTUS2 NDEL1 NUP62 PICK1 POU6F2 PPFIA1 PPFIBP2 PPP1R13B PRKAR1B PRTFDC1 SNCA SNTA1 SNTG1 SNTG2 SPZ1 SSBP3 TFIP11 TRAF2 TRIM27 TRIM37 TRIM54 TSACC TXLNA USHBP1 UTRN VCP VPS52 ZBTB9 ZRANB1
Entrez ID		84654	1838
HPRD ID		15440	09091
Ensembl ID		ENSG00000164299	ENSG00000138101
Uniprot IDs		A0A140VKA5 Q9BXG8	B7Z202 B7Z6A9 E7EVB6 E9PEY4 O60941 Q1I0L3
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Maturation Amyloid Fibril Formation Protein Serine/threonine Kinase Binding Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Regulation Of Cellular Response To Stress Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Positive Regulation Of RNA Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Developmental Maturation Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Positive Regulation Of Cell Differentiation Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling DNA-binding Transcription Factor Binding MRF Binding Protein Demethylase Activity Regulation Of Spontaneous Synaptic Transmission	Cytoskeleton Syntrophin Complex Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Dystrophin-associated Glycoprotein Complex Cytoskeleton Organization Intermediate Filament Organization Supramolecular Fiber Organization Keratin Filament Organelle Organization Intermediate Filament Actin-based Cell Projection Protein Binding SCAR Complex Synaptic Vesicle Transport Vesicle Transport Along Microtubule Cytosol Microtubule Binding Establishment Of Vesicle Localization Sarcolemma Vesicle Cytoskeletal Trafficking Retrograde Axonal Transport Axon Cytoplasm Vesicle Localization Cytoplasm Axonal Transport Epithelial Cell Differentiation Identical Protein Binding Cytosolic Transport Microtubule-based Process Retrograde Neuronal Dense Core Vesicle Transport De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Morphogenesis Of An Epithelium Centriole Assembly Aggresome Assembly Signaling Adaptor Activity Mitotic Centrosome Separation De Novo Centriole Assembly Filopodium Axo-dendritic Transport Intracellular Transport Negative Regulation Of Cytoskeleton Organization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Organelle Transport Along Microtubule Stress Granule Disassembly Regulation Of Actin Nucleation Regulation Of Sodium Ion Transmembrane Transport Actin Binding
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