GNPAT and GPR3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GNPAT	GPR3
Description		glyceronephosphate O-acyltransferase	G protein-coupled receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane Cell Junction	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Catalytic Activity O-acyltransferase Activity Glycerone-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity	G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Synapse Assembly Ether Lipid Biosynthetic Process Cerebellum Morphogenesis Paranodal Junction Assembly Myelination Membrane Organization	Sphingosine-1-phosphate Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Meiotic Nuclear Division Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of PA Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)
GWAS
Interacting Genes		6 interacting genes: AGPS GPR3 HSPB1 PEX5 RAB35 VDR	3 interacting genes: GNPAT RXYLT1 ZNF593
Entrez ID		8443	2827
HPRD ID		04120	02587
Ensembl ID		ENSG00000116906	ENSG00000181773
Uniprot IDs		O15228	F1DAM5 P46089
PDB IDs			8U8F 8WW2 8X2K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Peroxisome Matrix Targeting Signal-1 Binding Peroxisomal Matrix Peroxisome Targeting Sequence Binding Peroxisomal Membrane Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Bile Acid Nuclear Receptor Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Lithocholic Acid Binding Alkylglycerone-phosphate Synthase Activity Regulation Of Protein Kinase C Signaling Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Vitamin D Binding Positive Regulation Of Apoptotic Process Involved In Morphogenesis Sphingosine-1-phosphate Receptor Activity Anterograde Axonal Protein Transport Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Phosphate Transport Plasma Membrane To Endosome Transport Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Protein Transport Along Microtubule Response To Growth Factor Contractile Muscle Fiber Protein Unfolding Protein Import Into Peroxisome Matrix Phosphate Ion Transmembrane Transport Ether Lipid Biosynthetic Process Protein Localization To Endosome Cell Projection Membrane	Glycerone-phosphate O-acyltransferase Activity Ribitol Beta-1,4-xylosyltransferase Activity Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription Regulatory Region DNA Binding Cerebellum Morphogenesis Paranodal Junction Assembly Preribosome Binding Ether Lipid Biosynthetic Process Protein O-linked Glycosylation Via Mannose Negative Regulation Of DNA Binding Regulation Of Transcription Regulatory Region DNA Binding Ether Lipid Metabolic Process O-acyltransferase Activity Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Ribonucleoprotein Complex Binding Regulation Of DNA Binding Peroxisomal Matrix
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