GNPAT

Description		glyceronephosphate O-acyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane Cell Junction
	Molecular Function	Catalytic Activity O-acyltransferase Activity Glycerone-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Synapse Assembly Ether Lipid Biosynthetic Process Cerebellum Morphogenesis Paranodal Junction Assembly Myelination Membrane Organization
Pathways		Synthesis of PA Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)
GWAS
Interacting Genes		6 interacting genes: AGPS GPR3 HSPB1 PEX5 RAB35 VDR
Entrez ID		8443
HPRD ID		04120
Ensembl ID		ENSG00000116906
Uniprot IDs		O15228
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Peroxisome Matrix Targeting Signal-1 Binding Peroxisomal Matrix Peroxisome Targeting Sequence Binding Peroxisomal Membrane Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Bile Acid Nuclear Receptor Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Lithocholic Acid Binding Alkylglycerone-phosphate Synthase Activity Regulation Of Protein Kinase C Signaling Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Vitamin D Binding Positive Regulation Of Apoptotic Process Involved In Morphogenesis Sphingosine-1-phosphate Receptor Activity Anterograde Axonal Protein Transport Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Phosphate Transport Plasma Membrane To Endosome Transport Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Protein Transport Along Microtubule Response To Growth Factor Contractile Muscle Fiber Protein Unfolding Protein Import Into Peroxisome Matrix Phosphate Ion Transmembrane Transport Ether Lipid Biosynthetic Process Protein Localization To Endosome Cell Projection Membrane
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