UTF1 and ATF2

Number of citations of the paper that reports this interaction (PMID 9524124)
36

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		UTF1	ATF2
Gene Name		undifferentiated embryonic cell transcription factor 1	activating transcription factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break
	Molecular Function	Transcription Coactivator Activity Protein Binding HMG Box Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding CAMP Response Element Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Male Gonad Development Positive Regulation Of Transcription From RNA Polymerase II Promoter	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Histone Acetylation Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Adipose Tissue Development Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways			Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade HATs acetylate histones Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Chromatin organization TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Mitochondrial biogenesis Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Chromatin modifying enzymes Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ATF2 SOX10 SOX8	55 interactors: APP AR ATF3 ATF4 ATF7 BACH1 BATF BATF3 CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 EDF1 ETS1 EXOSC8 FOS FOSL1 GTF2F2 H2AFY HIST2H2BE HMGA1 IRF2BP1 JDP2 JUN KIFC3 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PML PRKCE RB1 RPS6KA5 RUVBL2 SMAD3 SMAD4 SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1
Entrez ID		8433	1386
HPRD ID		11964	00443
Ensembl ID		ENSG00000171794	ENSG00000115966
Uniprot IDs		Q5T230	A4D7V5 P15336
PDB IDs			1BHI 1T2K 4H36
Enriched GO Terms of Interacting Partners?		Enteric Nervous System Development Adipose Tissue Development Autonomic Nervous System Development Neural Crest Cell Migration Positive Regulation Of Gliogenesis Neural Crest Cell Development Oligodendrocyte Differentiation Neural Crest Cell Differentiation Transcription From RNA Polymerase II Promoter Regulation Of Gliogenesis Peripheral Nervous System Development Mesenchymal Cell Development Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Cell Maturation Ameboidal-type Cell Migration Glial Cell Differentiation Positive Regulation Of Transcription, DNA-templated Mesenchyme Development Retinal Rod Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gliogenesis Connective Tissue Development Positive Regulation Of Cellular Biosynthetic Process Stem Cell Development Renal Vesicle Induction Tissue Development Astrocyte Fate Commitment Metanephric Nephron Tubule Formation Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Ureter Morphogenesis Metanephric Tubule Formation Positive Regulation Of Neurogenesis Regulation Of Transforming Growth Factor Beta2 Production Metanephric Nephron Tubule Morphogenesis Transcription, DNA-templated Tube Morphogenesis RNA Biosynthetic Process Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Intra-S DNA Damage Checkpoint Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Cell Development In Utero Embryonic Development Epithelial Cell Differentiation	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Biosynthetic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Response To External Stimulus Negative Regulation Of Gene Expression Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		abbreviated biochemically chimaeras chimaeric classically cooperatively demethylase derepression execute execution hampers ipsc ipscs kdm6a opted osk oskm pgcs pluripotency pluripotent pou5f1 primordial reprogram reprogramming robustly safeguards sall1 sall4 utx	assayed atp compete competes diphosphorylated enzyme equal equally gly gst homogeneously ic50 inactive km monophosphorylated p38 preparations pyridinylimidazole pyridinylimidazoles s2 sb202190 sb203580 thr threonine transducing tritiated tyr ubiquitous unphosphorylated
Tagcloud (Difference) ?		abbreviated biochemically chimaeras chimaeric classically cooperatively demethylase derepression execute execution hampers ipsc ipscs kdm6a opted osk oskm pgcs pluripotency pluripotent pou5f1 primordial reprogram reprogramming robustly safeguards sall1 sall4 utx	assayed atp compete competes diphosphorylated enzyme equal equally gly gst homogeneously ic50 inactive km monophosphorylated p38 preparations pyridinylimidazole pyridinylimidazoles s2 sb202190 sb203580 thr threonine transducing tritiated tyr ubiquitous unphosphorylated
Tagcloud (Intersection) ?