GINS4 and IDO2

		GINS4	IDO2
Description		GINS complex subunit 4	indoleamine 2,3-dioxygenase 2
Image			No pdb structure
GO Annotations	Cellular Component	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Replication DNA-templated DNA Replication	Immune System Process L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine 'de Novo' NAD+ Biosynthetic Process From L-tryptophan
Pathways		Unwinding of DNA Unwinding of DNA	Tryptophan catabolism
Drugs
Diseases
GWAS			Schizophrenia x sex interaction ( 34099189)
Interacting Genes		12 interacting genes: - BIN3 CTNNBIP1 DMAP1 GINS2 KIF16B LHX8 PBX4 POLA1 POLD1 POLE PPP1R13B	2 interacting genes: BANP LZTS1
Entrez ID		84296	169355
HPRD ID		11583	14113
Ensembl ID		ENSG00000147536	ENSG00000188676
Uniprot IDs		Q9BRT9	Q6ZQW0
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		DNA Polymerase Activity DNA-directed DNA Polymerase Activity DNA Replication Proofreading DNA Synthesis Involved In DNA Repair Leading Strand Elongation DNA Replication DNA-templated DNA Replication Nucleotide-excision Repair, DNA Gap Filling DNA Repair DNA Strand Elongation Involved In DNA Replication Nucleotidyltransferase Activity DNA Biosynthetic Process Base-excision Repair, Gap-filling DNA Strand Elongation DNA Metabolic Process DNA Damage Response 4 Iron, 4 Sulfur Cluster Binding Actin Cortical Patch Localization Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Iron-sulfur Cluster Binding Beta-catenin-ICAT Complex Indoleamine 2,3-dioxygenase Activity Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Unidimensional Cell Growth Tryptophan 2,3-dioxygenase Activity Mitotic DNA Replication Initiation Nucleobase-containing Compound Biosynthetic Process Alpha DNA Polymerase:primase Complex Error-free Translesion Synthesis Delta DNA Polymerase Complex Epsilon DNA Polymerase Complex Single-stranded DNA 3'-5' DNA Exonuclease Activity GINS Complex Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Ethanol L-tryptophan Catabolic Process To Kynurenine Cellular Response To Stress DNA Replication, Synthesis Of Primer Nucleotide-excision Repair Complex Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II
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