FCF1 and SPDYC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCF1	SPDYC
Description		FCF1 rRNA-processing protein	speedy/RINGO cell cycle regulator family member C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Small-subunit Processome	Nucleus Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Anxiety ( 33859377) Depression ( 33859377) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: APP BCCIP SPDYC UTP23	4 interacting genes: ARPP19 FCF1 LZTS1 PAX6
Entrez ID		51077	387778
HPRD ID		12633	17367
Ensembl ID		ENSG00000119616	ENSG00000204710
Uniprot IDs		G3V1S4 Q4FZ45 Q9Y324	Q5MJ68
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Kinase Regulator Activity Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Small Ribosomal Subunit RRNA Binding Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Forebrain-midbrain Boundary Formation Type B Pancreatic Cell Differentiation Pancreatic A Cell Development Forebrain Neuron Fate Commitment Habenula Development Oligodendrocyte Cell Fate Specification Ventral Spinal Cord Development Cornea Development In Camera-type Eye Pallium Development Salivary Gland Morphogenesis Formation Of Anatomical Boundary Iris Morphogenesis Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Phosphatase Inhibitor Activity Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Dorsal/ventral Axis Specification HMG Box Domain Binding Co-SMAD Binding Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Negative Regulation Of Neuroblast Proliferation Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation
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