ZCCHC9 and EMG1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ZCCHC9	EMG1
Description		zinc finger CCHC-type containing 9	EMG1 N1-specific pseudouridine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Small-subunit Processome
	Molecular Function	Nucleic Acid Binding RNA Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Protein Binding Methyltransferase Activity Transferase Activity RRNA Binding Identical Protein Binding RRNA (pseudouridine) Methyltransferase Activity
	Biological Process		Blastocyst Development RRNA Processing Nucleologenesis Methylation Ribosome Biogenesis Ribosomal Small Subunit Biogenesis RRNA Base Methylation
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases			Bowen-Conradi syndrome (BCS)
GWAS
Interacting Genes		3 interacting genes: EMG1 FAM98A UBTFL1	20 interacting genes: ANXA3 APP CEBPA CFTR CTSE FAM74A4 FAM98A HIVEP1 HSD3B7 IL7R KHDRBS1 MCPH1 NAA80 PRC1 PSMB7 PSME1 SLC25A38 SUMO2 ZCCHC9 ZNF768
Entrez ID		84240	10436
HPRD ID		15704	12803
Ensembl ID		ENSG00000131732	ENSG00000126749
Uniprot IDs		Q8N567	Q92979
PDB IDs			5FAI 7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		RRNA (pseudouridine) Methyltransferase Activity Macromolecule Methylation Nucleologenesis RRNA Base Methylation Nucleolus Organization RNA Metabolic Process Methylation TRNA-splicing Ligase Complex RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Blastocyst Growth RNA Polymerase I Preinitiation Complex Assembly TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methyltransferase Activity Positive Regulation Of Ruffle Assembly Transcription By RNA Polymerase I RRNA Methylation Nucleic Acid Metabolic Process Blastocyst Development Regulation Of Ruffle Assembly Positive Regulation Of Transcription By RNA Polymerase I RRNA Modification Protein Methylation RRNA Binding Regulation Of Transcription By RNA Polymerase I Embryo Implantation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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