KAT8 and CLEC4A

		KAT8	CLEC4A
Description		lysine acetyltransferase 8	C-type lectin domain family 4 member A
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Chromosome Mitochondrion Nuclear Matrix Nuclear Lumen NuA4 Histone Acetyltransferase Complex NSL Complex MLL1 Complex MSL Complex	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Enzyme Binding Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Epithelial To Mesenchymal Transition Chromatin Organization Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Skeletal Muscle Satellite Cell Differentiation Neurogenesis Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Post-embryonic Hemopoiesis Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oogenesis Regulation Of MRNA Processing Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Membraneless Organelle Assembly Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Regulation Of Mitochondrial Transcription	Negative Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Plasmacytoid Dendritic Cell Antigen Processing And Presentation Cell Adhesion Cell Surface Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production CD8-positive, Alpha-beta T Cell Activation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Antifungal Innate Immune Response
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Dectin-2 family
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		15 interacting genes: ATM BAZ1B BAZ2A CEBPA FOXP3 H2AC8 H3C1 H4C1 H4C7 KMT2A PAF1 PLAU RNF2 TP53 TP53BP1	2 interacting genes: LMNA PTPN6
Entrez ID		84148	50856
HPRD ID		11381	05604
Ensembl ID		ENSG00000103510	ENSG00000111729
Uniprot IDs		Q9H7Z6	Q9UMR7
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR 8W13	5B1W 5B1X
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization DNA Binding Epigenetic Regulation Of Gene Expression Response To X-ray Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein Heterodimerization Activity Structural Constituent Of Chromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromosome Nucleosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of DNA Recombination Negative Regulation Of Cell Population Proliferation Cellular Response To X-ray Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Assembly DNA Repair Complex DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Chromosome Organization Replicative Senescence Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Organelle Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Or Lymphoid Organ Development Site Of Double-strand Break DNA Damage Checkpoint Signaling Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Regulation Of Integrin-mediated Signaling Pathway	Nuclear Lumen DNA Double-strand Break Attachment To Nuclear Envelope Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression Nuclear Matrix Cell Development Heterochromatin Formation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Hemopoiesis Epididymis Development Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Protein Propionyltransferase Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Epigenetic Regulation Of Gene Expression CD27 Signaling Pathway Myeloid Cell Differentiation Negative Regulation Of Mast Cell Activation Involved In Immune Response MSL Complex Post-embryonic Hemopoiesis Negative Regulation Of Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Phosphorylation-dependent Protein Binding Negative Regulation Of Mast Cell Activation Inflammatory Response To Wounding Regulation Of Neutrophil Activation Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Alpha-beta T Cell Receptor Complex Neutrophil Activation Involved In Immune Response Negative Regulation Of Cytokine Production Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of B Cell Receptor Signaling Pathway NSL Complex Skeletal Muscle Satellite Cell Differentiation Histone H4K8 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Mitochondrial Transcription Histone H4 Acetyltransferase Activity Nuclear Lamina Negative Regulation Of Biosynthetic Process Regulation Of Inflammatory Response To Wounding
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