HYAL2

Name	hyaluronidase 2
Structure	No pdb structure
Interactors	16 interactors: CYSRT1 FHL3 KRT31 KRT34 KRTAP1-1 KRTAP10-3 KRTAP3-2 KRTAP6-2 KRTAP6-3 MST1R PELI2 SMAD2 SMAD3 SMAD4 TRIM54 WWOX
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Endoplasmic Reticulum Cytosol Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex Side Of Membrane
	Molecular Function	Virus Receptor Activity Transcription Coactivator Activity Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Enzyme Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Hyaluronoglucuronidase Activity Transforming Growth Factor Beta Binding
	Biological Process	Response To Reactive Oxygen Species Kidney Development Hematopoietic Progenitor Cell Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Response To Virus Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Urine Volume Monocyte Activation Positive Regulation Of Protein Import Into Nucleus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Symbiont Entry Into Host Cell Skeletal System Morphogenesis Positive Regulation Of Inflammatory Response Cartilage Development Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Renal Water Absorption Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways	Hyaluronan metabolism Hyaluronan degradation
GWAS	Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	8692
HPRD ID	04649
Ensembl ID	ENSG00000068001
Uniprot IDs	Q12891
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Intermediate Filament Keratin Filament SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Response To Transforming Growth Factor Beta SMAD Protein Signal Transduction R-SMAD Binding Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Activin Receptor Signaling Pathway Endoderm Development Mesoderm Morphogenesis Gastrulation Pericardium Development Trophoblast Cell Migration Epithelial Cell Differentiation Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Transforming Growth Factor Beta Stimulus Tissue Morphogenesis Tissue Development Embryonic Foregut Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal System Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Extrinsic Apoptotic Signaling Pathway Response To Growth Factor Regulation Of Extracellular Matrix Assembly Response To Glucose Morphogenesis Of An Epithelium Ameboidal-type Cell Migration Osteoblast Differentiation Adrenal Gland Development Response To Monosaccharide Positive Regulation Of Extracellular Matrix Organization Epidermis Development Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytosol Response To Carbohydrate