TLN2 and PIP5K1C

Number of citations of the paper that reports this interaction (PMID 12422219)
105

Data Source:
HPRD (in vitro)

		TLN2	PIP5K1C
Gene Name		talin 2	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Synapse	Phagocytic Cup Uropod Nucleus Cytosol Focal Adhesion Endomembrane System Ruffle Membrane
	Molecular Function	Actin Binding Insulin Receptor Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Talin Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell Adhesion	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Cytoskeletal Anchoring At Plasma Membrane Axon Guidance Synaptic Vesicle Exocytosis Single Organismal Cell-cell Adhesion Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Platelet Aggregation Clathrin-mediated Endocytosis
Pathways			Synthesis of PIPs at the plasma membrane Axon guidance Metabolism of lipids and lipoproteins Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: PIP5K1C	9 interactors: AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 LRP2 TLN2
Entrez ID		83660	23396
HPRD ID		09555	05834
Ensembl ID		ENSG00000171914	ENSG00000186111
Uniprot IDs		Q9Y4G6	O60331
PDB IDs			3H1Z 3H85
Enriched GO Terms of Interacting Partners?		Cytoskeletal Anchoring At Plasma Membrane Synaptic Vesicle Endocytosis Clathrin-mediated Endocytosis Synaptic Vesicle Recycling Platelet Aggregation Adherens Junction Assembly Neutrophil Chemotaxis Neutrophil Migration Synaptic Vesicle Exocytosis Granulocyte Chemotaxis Phosphatidylinositol Phosphorylation Adherens Junction Organization Lipid Phosphorylation Leukocyte Chemotaxis Neurotransmitter Secretion Synaptic Vesicle Transport Phosphatidylinositol Biosynthetic Process Regulation Of Neurotransmitter Levels Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Neurotransmitter Transport Cell Chemotaxis Platelet Activation Glycerophospholipid Biosynthetic Process Cell Junction Assembly Lipid Modification Establishment Of Vesicle Localization Cell-cell Junction Organization Vesicle Localization Phosphatidylinositol Metabolic Process Leukocyte Migration Phospholipid Biosynthetic Process Phagocytosis Glycerophospholipid Metabolic Process Establishment Of Organelle Localization Homotypic Cell-cell Adhesion Exocytosis Receptor-mediated Endocytosis Glycerolipid Metabolic Process Phospholipid Metabolic Process Axon Guidance Organelle Localization Blood Coagulation Hemostasis Secretion By Cell Single Organismal Cell-cell Adhesion Axonogenesis Lipid Biosynthetic Process Axon Development	Cellular Protein Localization Cellular Localization Vesicle-mediated Transport Protein Localization Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Of Protein Localization Regulation Of Dendritic Spine Development Regulated Secretory Pathway Apoptotic Process Programmed Cell Death Regulation Of B Cell Cytokine Production Synapse Assembly Cell Death Death Regulation Of Defense Response To Virus Cell Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Forebrain Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Cell Adhesion Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Dendrite Development Nervous System Development Cellular Response To Molecule Of Fungal Origin Cell-cell Junction Assembly Regulation Of Immune System Process Negative Regulation Of Synaptic Plasticity Protein Transport Response To Molecule Of Fungal Origin Endocytosis Intracellular Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Generation Of Neurons Serine Phosphorylation Of STAT3 Protein Cellular Response To Indole-3-methanol Regulation Of Cell Differentiation Synapse Organization Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Serine Phosphorylation Of STAT Protein Neurogenesis Brain Development Cell Junction Assembly Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Protein Export From Nucleus
Tagcloud ?			ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste
Tagcloud (Difference) ?			ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste
Tagcloud (Intersection) ?