TMEM47 and SPACA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM47	SPACA1
Description		transmembrane protein 47	sperm acrosome associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Anchoring Junction	Acrosomal Vesicle Inner Acrosomal Membrane Acrosomal Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell-cell Adhesion	Acrosome Assembly Spermatogenesis
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 23412934)	Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		4 interacting genes: FAM209A SPACA1 SUSD3 TMEM179B	25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47
Entrez ID		83604	81833
HPRD ID		06741	15419
Ensembl ID		ENSG00000147027	ENSG00000118434
Uniprot IDs		Q9BQJ4	Q9HBV2
PDB IDs
Enriched GO Terms of Interacting Partners?		Inner Acrosomal Membrane Male Gamete Generation Gamete Generation Acrosomal Membrane Spermatogenesis Acrosome Assembly Secretory Granule Organization Developmental Process Involved In Reproduction Nuclear Inner Membrane Ficolin-1-rich Granule Membrane Azurophil Granule Membrane	Membrane Bleb Assembly Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Endosome Membrane Multivesicular Body Membrane Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Mitochondrion Autophagosome Adaptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle
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