HIST1H2BC and COPRS

Number of citations of the paper that reports this interaction (PMID 18404153)
25

Data Source:
BioGRID (pull down)

		HIST1H2BC	COPRS
Gene Name		histone cluster 1, H2bc	coordinator of PRMT5, differentiation stimulator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Protein Binding Histone Binding
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Histone H4-R3 Methylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484)
Protein-Protein Interactions		2 interactors: COPRS TP53BP2	8 interactors: CBFB HIST1H2BC HIST2H2AC HIST2H3C HIST4H4 PRMT5 RUNX1 WDR77
Entrez ID		8347	55352
HPRD ID		13656	13675
Ensembl ID			ENSG00000172301
Uniprot IDs		B2R4S9 P62807	H9KV77 Q9NQ92
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H4-R3 Methylation Histone Arginine Methylation Peptidyl-arginine Methylation	DNA Methylation On Cytosine Chromatin Silencing At RDNA Definitive Hemopoiesis Cellular Macromolecular Complex Assembly Chromatin Organization Chromatin Silencing Spliceosomal SnRNP Assembly DNA Methylation Chromosome Organization Gene Expression Methylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Myeloid Cell Differentiation DNA Modification Gene Silencing Positive Regulation Of Progesterone Secretion Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Regulation Of Transcription, DNA-templated Nucleosome Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Assembly Histone H4-K20 Demethylation Regulation Of Progesterone Secretion Nucleosome Organization Nucleobase-containing Compound Metabolic Process Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Hair Follicle Cell Proliferation Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of Gene Expression Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation DNA Packaging Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Negative Regulation Of Granulocyte Differentiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Nitrogen Compound Metabolic Process Myeloid Cell Differentiation
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