MIR21 and ZFR

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR21	ZFR
Description		microRNA 21	zinc finger RNA binding protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm RISC Complex Extracellular Exosome Extracellular Vesicle	Nucleus Chromosome Cytoplasm
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Blood Vessel Development Positive Regulation Of Cytokine Production Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Angiogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-21 Production Collagen Metabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Rac Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Phenotypic Switching Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Inflammatory Response Negative Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of Cartilage Development Endothelial Tube Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Virus Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cellular Response To Hypoxia Negative Regulation Of Arginine Catabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Chondrocyte Proliferation Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Resveratrol Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Replicative Senescence Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Tube Morphogenesis Retinal Cell Apoptotic Process Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Monocyte count ( 29403010)	Metabolite levels ( 23823483)
Interacting Genes		95 interacting genes: AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUFIP2 PATL1 PDCD11 PGAM5 PTBP1 PTBP3 PTCD3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF106	46 interacting genes: CEBPA HMGB2 MIR1-1 MIR106A MIR106B MIR128-1 MIR128-2 MIR138-2 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR18A MIR18B MIR19A MIR19B2 MIR200C MIR206 MIR20B MIR21 MIR214 MIR222 MIR29B1 MIR29B2 MIR29C MIR31 MIR34B MIR363 MIR9-1 MIR9-2 MIR9-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I RNF10 USP7
Entrez ID		406991	51663
HPRD ID			15730
Ensembl ID		ENSG00000284190	ENSG00000056097
Uniprot IDs			Q05D65 Q96KR1
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of RNA Catabolic Process MiRNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Catalytic Step 2 Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Metabolic Process Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Ligase Activity P-body Nucleolus Positive Regulation Of Gene Expression Pre-mRNA Binding	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Extracellular Vesicle Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Space Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process
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