CAPZB and MTPN

Number of citations of the paper that reports this interaction (PubMedID 12488317)
0

Data Source:
HPRD (in vivo)

		CAPZB	MTPN
Description		capping actin protein of muscle Z-line subunit beta	myotrophin
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Brush Border F-actin Capping Protein Complex Postsynaptic Density Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cortical Cytoskeleton Asymmetric Synapse Extracellular Exosome WASH Complex Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Sperm Head-tail Coupling Apparatus	Nucleus Cytoplasm Cytosol F-actin Capping Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Cadherin Binding
	Biological Process	Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cell Morphogenesis Cell Projection Organization Lamellipodium Assembly Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping	Regulation Of Translation Regulation Of Cell Size Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Striated Muscle Tissue Development Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Barbed-end Actin Filament Capping
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic RHOD GTPase cycle RHOF GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease and psoriasis ( 22482804) Heel bone mineral density ( 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Lead levels in blood ( 25820613) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Serum thyroid-stimulating hormone levels ( 24852370) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Thyroid volume ( 21565293)	Alcoholic chronic pancreatitis ( 28754779) Mean platelet volume ( 32888494) Platelet count ( 27863252) Platelet distribution width ( 27863252 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		10 interacting genes: BCCIP CDC42 CEBPA CFTR MRPL20 MTPN PTN RPP14 SIRPA VHL	7 interacting genes: CAPZB CEBPA MAPK1 NFKB1 REL RELA RIPK4
Entrez ID		832	136319
HPRD ID		11872	07574
Ensembl ID		ENSG00000077549	ENSG00000105887
Uniprot IDs		A0A384MR50 B1AK85 B1AK88 B4DWA6 P47756 Q7L4N0	P58546 Q69YG1
PDB IDs		8F8Q	3AAA 7DF7 7DSA 7DSB
Enriched GO Terms of Interacting Partners?		Organelle Localization Mononuclear Cell Migration Positive Regulation Of Cell Division Apolipoprotein A-I Receptor Binding Macrophage Differentiation Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Leukocyte Migration Protein-containing Complex Cellular Response To Cytokine Stimulus Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Integrin-mediated Signaling Pathway Cellular Response To Type II Interferon Sterol Metabolic Process Cholesterol Metabolic Process CHOP-C/EBP Complex Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Dendrite Regeneration Ossification Involved In Bone Remodeling Protein Phosphatase Inhibitor Activity Endoribonuclease Complex Ribonuclease P Complex Kinase Regulator Activity Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Protein Binding Involved In Heterotypic Cell-cell Adhesion Cellular Response To Interleukin-12 Response To Interleukin-12	Response To Peptide Response To Cytokine Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor NF-kappaB P50/p65 Complex Non-canonical NF-kappaB Signal Transduction Cellular Response To Cytokine Stimulus Response To Nicotine NF-kappaB Complex Canonical NF-kappaB Signal Transduction Cellular Response To Nicotine Intracellular Signaling Cassette Actinin Binding Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response Cellular Response To Angiotensin Cellular Response To Interleukin-6 DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Immune System Process Sequence-specific DNA Binding Positive Regulation Of Defense Response Response To Interleukin-6 Positive Regulation Of Inflammatory Response Response To Angiotensin Inflammatory Response Response To Muscle Stretch Signal Transduction Involved In Regulation Of Gene Expression DNA-binding Transcription Factor Activity Transcription Regulator Complex Immune Response-activating Cell Surface Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Gland Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding B Cell Receptor Signaling Pathway Response To Lipid Regulation Of Immune System Process Response To Lipopolysaccharide Regulation Of Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Negative Regulation Of Cytokine Production RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Immune Response-activating Signaling Pathway Positive Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction
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