CAPZB

Name	capping actin protein of muscle Z-line subunit beta
Structure
Interactors	10 interactors: BCCIP CDC42 CEBPA CFTR MRPL20 MTPN PTN RPP14 SIRPA VHL
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Brush Border F-actin Capping Protein Complex Postsynaptic Density Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cortical Cytoskeleton Asymmetric Synapse Extracellular Exosome WASH Complex Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Actin Binding Protein Binding Cadherin Binding
	Biological Process	Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cell Morphogenesis Cell Projection Organization Lamellipodium Assembly Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping
Pathways	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic RHOD GTPase cycle RHOF GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
GWAS	Appendicular lean mass ( 33097823 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease and psoriasis ( 22482804 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Hyperthyroidism ( 30367059 ) Hypothyroidism ( 30367059 27182965 ) Lead levels in blood ( 25820613 ) Lung adenocarcinoma (survival time) in never smokers ( 32699080 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Serum thyroid-stimulating hormone levels ( 24852370 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Thyroid function ( 22494929 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 25743335 ) Thyroid volume ( 21565293 )
Entrez ID	832
HPRD ID	11872
Ensembl ID	ENSG00000077549
Uniprot IDs	A0A384MR50 B1AK85 B1AK88 B4DWA6 P47756 Q7L4N0
PDB IDs	8F8Q
GO Terms Enriched among Interactors ?	Organelle Localization Mononuclear Cell Migration Positive Regulation Of Cell Division Apolipoprotein A-I Receptor Binding Macrophage Differentiation Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Leukocyte Migration Protein-containing Complex Cellular Response To Cytokine Stimulus Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Integrin-mediated Signaling Pathway Cellular Response To Type II Interferon Sterol Metabolic Process Cholesterol Metabolic Process CHOP-C/EBP Complex Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Dendrite Regeneration Ossification Involved In Bone Remodeling Protein Phosphatase Inhibitor Activity Endoribonuclease Complex Ribonuclease P Complex Kinase Regulator Activity Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Protein Binding Involved In Heterotypic Cell-cell Adhesion Cellular Response To Interleukin-12 Response To Interleukin-12