COLQ and BCHE

Number of citations of the paper that reports this interaction (PMID 10529218)
9

Data Source:
HPRD (in vitro)

		COLQ	BCHE
Gene Name		collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	butyrylcholinesterase
Image
Gene Ontology Annotations	Cellular Component	Collagen Trimer Basal Lamina Extracellular Space Cell Junction Synapse	Extracellular Region Nuclear Envelope Lumen Endoplasmic Reticulum Lumen Membrane Blood Microparticle
	Molecular Function	Protein Binding	Beta-amyloid Binding Catalytic Activity Acetylcholinesterase Activity Cholinesterase Activity Enzyme Binding Choline Binding Identical Protein Binding
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Asymmetric Protein Localization	Learning Negative Regulation Of Cell Proliferation Neuroblast Differentiation Choline Metabolic Process Response To Drug Response To Alkaloid Cellular Protein Metabolic Process Cocaine Metabolic Process Negative Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Folic Acid
Pathways			Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses
Drugs			Choline Tacrine Dipivefrin Pyridostigmine Galantamine Isoflurophate Pralidoxime Malathion Hexafluronium Demecarium Rivastigmine Edrophonium Echothiophate Mivacurium Beta-D-Mannose Diethylphosphono Group Methylphosphinic Acid Alpha-D-Mannose Butanoic Acid 9-N-Phenylmethylamino-Tacrine 2-(N-Morpholino)-Ethanesulfonic Acid Ethyl Dihydrogen Phosphate Butyrylthiocholine Monoisopropyl Ester Phosphonic Acid Group DODECANESULFONATE ION 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE (1R)-MENTHYL HEXYL PHOSPHONATE GROUP (1S)-MENTHYL HEXYL PHOSPHONATE GROUP ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE
Diseases
GWAS			Alzheimer's disease biomarkers ( 23419831) Aspirin hydrolysis (plasma) ( 23508960) Butyrylcholinesterase levels ( 21862451) Cardiovascular disease risk factors ( 21943158) Heart failure ( 20445134)
Protein-Protein Interactions		3 interactors: ACHE BCHE MUSK	1 interactors: COLQ
Entrez ID		8292	590
HPRD ID		04328	01519
Ensembl ID		ENSG00000206561	ENSG00000114200
Uniprot IDs		Q9Y215	D3DNN4 P06276
PDB IDs		1VZJ	1EHO 1EHQ 1KCJ 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2PM8 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ 2XQK 2Y1K 3DJY 3DKK 3O9M 4AQD 4AXB 4B0O 4B0P 4BBZ 4BDS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission Cellular Biogenic Amine Metabolic Process Amine Metabolic Process Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Cocaine Metabolic Process Synapse Organization Acetylcholine Catabolic Process Acetylcholine Catabolic Process In Synaptic Cleft Neuroblast Differentiation Learning Or Memory Cognition Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Synaptic Transmission Receptor Biosynthetic Process Alcohol Metabolic Process Regulation Of Synaptic Transmission, Cholinergic Choline Metabolic Process Neurotransmitter Receptor Metabolic Process Single-organism Behavior Skeletal Muscle Acetylcholine-gated Channel Clustering Alkaloid Metabolic Process Neurotransmitter Catabolic Process Response To Folic Acid Synaptic Transmission, Cholinergic Behavior Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Cell Differentiation Phosphatidylcholine Biosynthetic Process Neurotransmitter Metabolic Process Regulation Of Receptor Recycling Osteoblast Development Postsynaptic Membrane Organization Drug Metabolic Process Receptor Internalization Receptor Clustering Neuromuscular Junction Development Phosphatidylcholine Metabolic Process Neurological System Process Negative Regulation Of Signaling Regulation Of Synapse Assembly Positive Regulation Of Neuron Apoptotic Process Multicellular Organismal Development Positive Regulation Of Neuron Death Synapse Assembly Receptor Metabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity	Acetylcholine Catabolic Process In Synaptic Cleft Acetylcholine Catabolic Process Synaptic Transmission, Cholinergic Neurotransmitter Catabolic Process Asymmetric Protein Localization Neurotransmitter Metabolic Process Regulation Of Neurotransmitter Levels
Tagcloud ?		accomplished acetylcholinesterase ache ageing aldohexose bche butyrylcholinesterase characterised cholinergic cholinesterase d2m dibucaine hand1 hyper medicinal mega modeled ngf nlgn2 ortho pathwaylinker perceptive phosphomotifs retinol string trigliceridaemia unravelling upgma usinf	3mum 4mum 90mum acetylcholinesterase ache bromophenyl butyrylcholinesterase carbamoyl chloro chlorosalicylic cholinesterases comparatively dialkyl dichlorophenyl diethyl eel electricus electrophorus ellman equine galantamine halogenated ic50s phenylcarbamoyl phosphates rivastigmine salicylanilide salicylic spectrophotometric
Tagcloud (Difference) ?		accomplished ageing aldohexose characterised cholinergic cholinesterase d2m dibucaine hand1 hyper medicinal mega modeled ngf nlgn2 ortho pathwaylinker perceptive phosphomotifs retinol string trigliceridaemia unravelling upgma usinf	3mum 4mum 90mum bromophenyl carbamoyl chloro chlorosalicylic cholinesterases comparatively dialkyl dichlorophenyl diethyl eel electricus electrophorus ellman equine galantamine halogenated ic50s phenylcarbamoyl phosphates rivastigmine salicylanilide salicylic spectrophotometric
Tagcloud (Intersection) ?		acetylcholinesterase ache bche butyrylcholinesterase