COLQ and ACHE

Number of citations of the paper that reports this interaction (PMID 12609505)
2

Data Source:
HPRD (in vitro)

		COLQ	ACHE
Gene Name		collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	acetylcholinesterase (Yt blood group)
Image
Gene Ontology Annotations	Cellular Component	Collagen Trimer Basal Lamina Extracellular Space Cell Junction Synapse	Extracellular Region Basal Lamina Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Anchored Component Of Membrane Neuromuscular Junction Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Beta-amyloid Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Asymmetric Protein Localization	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development DNA Replication Acetylcholine Catabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Synaptic Transmission Nervous System Development Synapse Assembly Muscle Organ Development Cell Proliferation Response To Wounding Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Small Molecule Metabolic Process Neurotransmitter Receptor Biosynthetic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Secretion Protein Tetramerization Retina Development In Camera-type Eye
Pathways			Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses
Drugs			Choline Tacrine Gallamine Triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Ephedrine Neostigmine Monoisopropylphosphorylserine Huperaine A Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium Methylphosphonic Acid Ester Group Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose 2-(N-Morpholino)-Ethanesulfonic Acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
Diseases
GWAS			Heart rate ( 23583979) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 21490949)
Protein-Protein Interactions		3 interactors: ACHE BCHE MUSK	9 interactors: APP COL1A1 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		8292	43
HPRD ID		04328	00010
Ensembl ID		ENSG00000206561	ENSG00000087085
Uniprot IDs		Q9Y215	P22303
PDB IDs		1VZJ	1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission Cellular Biogenic Amine Metabolic Process Amine Metabolic Process Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Cocaine Metabolic Process Synapse Organization Acetylcholine Catabolic Process Acetylcholine Catabolic Process In Synaptic Cleft Neuroblast Differentiation Learning Or Memory Cognition Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Synaptic Transmission Receptor Biosynthetic Process Alcohol Metabolic Process Regulation Of Synaptic Transmission, Cholinergic Choline Metabolic Process Neurotransmitter Receptor Metabolic Process Single-organism Behavior Skeletal Muscle Acetylcholine-gated Channel Clustering Alkaloid Metabolic Process Neurotransmitter Catabolic Process Response To Folic Acid Synaptic Transmission, Cholinergic Behavior Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Cell Differentiation Phosphatidylcholine Biosynthetic Process Neurotransmitter Metabolic Process Regulation Of Receptor Recycling Osteoblast Development Postsynaptic Membrane Organization Drug Metabolic Process Receptor Internalization Receptor Clustering Neuromuscular Junction Development Phosphatidylcholine Metabolic Process Neurological System Process Negative Regulation Of Signaling Regulation Of Synapse Assembly Positive Regulation Of Neuron Apoptotic Process Multicellular Organismal Development Positive Regulation Of Neuron Death Synapse Assembly Receptor Metabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity	Extracellular Matrix Organization Extracellular Structure Organization Retinal Blood Vessel Morphogenesis Extracellular Matrix Disassembly Axon Guidance Retina Vasculature Morphogenesis In Camera-type Eye Neurotransmitter Catabolic Process Odontogenesis Blood Vessel Development Axonogenesis Vasculature Development Retina Vasculature Development In Camera-type Eye Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Chemotaxis Neurotransmitter Metabolic Process Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Head Development Neuron Projection Development Cell Projection Morphogenesis Neuromuscular Junction Development Cell Part Morphogenesis Cardiovascular System Development Tissue Development Cellular Response To Amino Acid Stimulus Organ Development Response To External Stimulus Collagen Catabolic Process Neuron Development Epithelial Tube Morphogenesis Organ Morphogenesis Embryonic Heart Tube Formation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Cellular Response To Fluoride Collagen Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Blood Vessel Morphogenesis Tube Morphogenesis Cell Differentiation Multicellular Organismal Metabolic Process Neuron Differentiation Cell Projection Organization Morphogenesis Of An Epithelium
Tagcloud ?		accomplished acetylcholinesterase ache ageing aldohexose bche butyrylcholinesterase characterised cholinergic cholinesterase d2m dibucaine hand1 hyper medicinal mega modeled ngf nlgn2 ortho pathwaylinker perceptive phosphomotifs retinol string trigliceridaemia unravelling upgma usinf	acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening
Tagcloud (Difference) ?		accomplished ageing aldohexose bche butyrylcholinesterase characterised cholinergic cholinesterase d2m dibucaine hand1 hyper medicinal mega modeled ngf nlgn2 ortho pathwaylinker perceptive phosphomotifs retinol string trigliceridaemia unravelling upgma usinf	amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening
Tagcloud (Intersection) ?		acetylcholinesterase ache