COLQ and ACHE

Number of citations of the paper that reports this interaction (PubMedID 12609505)
0

Data Source:
HPRD (in vitro)

		COLQ	ACHE
Description		collagen like tail subunit of asymmetric acetylcholinesterase	acetylcholinesterase (Yt blood group)
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GO Annotations	Cellular Component	Collagen Trimer Basement Membrane Extracellular Space Plasma Membrane Cell Junction Extracellular Matrix Neuromuscular Junction Synaptic Cleft Synapse	Extracellular Region Basement Membrane Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Neuromuscular Junction Synaptic Cleft Synapse Perinuclear Region Of Cytoplasm Side Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding	Amyloid-beta Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Identical Protein Binding Protein Homodimerization Activity Laminin Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Synaptic Assembly At Neuromuscular Junction Skeletal Muscle Acetylcholine-gated Channel Clustering Establishment Of Protein Localization To Membrane	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development Acetylcholine Catabolic Process Cell Adhesion Nervous System Development Synapse Assembly Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Amyloid Precursor Protein Metabolic Process Positive Regulation Of Protein Secretion Retina Development In Camera-type Eye Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways			Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
Drugs			Choline Tacrine Dipivefrin Gallamine triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Ranitidine Ethanol Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Neostigmine Monoisopropylphosphorylserine Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium Methylphosphinate Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium beta-L-fucose Huperzine B M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene N-acetyl-alpha-D-glucosamine 2-(N-morpholino)ethanesulfonic acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine NAP-226-90 (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM Zanapezil Huperzine A Phenserine Itopride Ganstigmine Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate Methylthioninium Diethylene glycol diethyl ether 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM Dimetacrine Terpinen-4-ol Tyrothricin Choline salicylate
Diseases		Congenital myasthenic syndrome
GWAS		Diverticular disease ( 28585551 30177863) Diverticulitis ( 28585551)	Bipolar disorder ( 31043756) Body mass index ( 29273807) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Type 2 diabetes ( 21490949)
Interacting Genes		5 interacting genes: ACHE BCHE MUSK SGTB SNCA	8 interacting genes: APP COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		8292	43
HPRD ID		04328	00010
Ensembl ID		ENSG00000206561	ENSG00000087085
Uniprot IDs		Q9Y215	P22303
PDB IDs		1VZJ	1B41 1F8U 1VZJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA 5HQ3 6CQT 6CQU 6CQV 6CQW 6CQX 6CQY 6CQZ 6F25 6NEA 6NTG 6NTH 6NTK 6NTL 6NTM 6NTN 6NTO 6O4W 6O4X 6O50 6O52 6O5R 6O5S 6O5V 6O66 6O69 6U34 6U37 6U3P 6WUV 6WUY 6WUZ 6WV1 6WVC 6WVO 6WVP 6WVQ 6ZWE 7D9O 7D9P 7D9Q 7E3D 7E3H 7RB5 7RB6 7RB7 7XN1 8AEN 8AEV 8DT2 8DT4 8DT5 8DT7
Enriched GO Terms of Interacting Partners?		Acetylcholine Catabolic Process Acetylcholinesterase Activity Cholinesterase Activity Regulation Of Receptor Recycling Carboxylic Ester Hydrolase Activity Negative Regulation Of Synaptic Transmission Synapse Organization Hsp70 Protein Binding Negative Regulation Of Synaptic Transmission, Cholinergic Receptor Internalization Neuromuscular Junction Cocaine Metabolic Process Positive Regulation Of Protein Geranylgeranylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Amyloid-beta Binding Response To Alkaloid Modulation Of Chemical Synaptic Transmission Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process TRC Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Identical Protein Binding Choline Binding Regulation Of Synapse Assembly Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Receptor-mediated Endocytosis Ribosome Molecular Adaptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Serine Hydrolase Activity Choline Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Neuroblast Differentiation Response To Iron(II) Ion Acetylcholine Binding Synapse Alkaloid Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial ATP Synthesis Coupled Electron Transport	Basement Membrane Extracellular Matrix Structural Constituent Laminin-1 Complex Laminin Complex Retinal Blood Vessel Morphogenesis Glycosphingolipid Binding Regulation Of Basement Membrane Organization Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Integrin-mediated Signaling Pathway Extracellular Matrix Regulation Of Integrin-mediated Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Glial Cell Development Endoplasmic Reticulum Lumen Cyclin D2-CDK6 Complex Morphogenesis Of An Epithelium Tube Morphogenesis Laminin-8 Complex Regulation Of Extracellular Matrix Organization Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Embryonic Heart Tube Formation Collagen Trimer Positive Regulation Of Muscle Cell Differentiation Acetylcholine Receptor Activator Activity PTB Domain Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Tissue Morphogenesis
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