BCHE and SEC11A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCHE	SEC11A
Description		butyrylcholinesterase	SEC11 homolog A, signal peptidase complex subunit
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Lumen Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Blood Microparticle	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Amyloid-beta Binding Catalytic Activity Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Enzyme Binding Choline Binding Identical Protein Binding Carboxylic Ester Hydrolase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Acetylcholine Catabolic Process Xenobiotic Metabolic Process Response To Nutrient Learning Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Neuroblast Differentiation Peptide Hormone Processing Choline Metabolic Process Response To Alkaloid Cocaine Metabolic Process Negative Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Folic Acid	Signal Peptide Processing Proteolysis Response To Virus
Pathways		Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin Aspirin ADME	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs		Choline Tacrine Dipivefrin Pyridostigmine Galantamine Isoflurophate Pralidoxime Malathion Donepezil Hexafluronium Demecarium Rivastigmine Edrophonium Echothiophate Ketamine Mivacurium Bambuterol Diethyl phosphonate Methylphosphinic Acid Butyric Acid 9-N-Phenylmethylamino-Tacrine 2-(N-morpholino)ethanesulfonic acid Ethyl dihydrogen phosphate Butyrylthiocholine Phenserine DODECANESULFONATE ION 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE (1R)-menthyl hexyl phosphonate group (1S)-menthyl hexyl phosphonate group Ethyl hydrogen diethylamidophosphate Dichlorvos Choline salicylate
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Aspirin hydrolysis (plasma) ( 23508960) Butyrylcholinesterase levels ( 21862451) Cardiovascular disease risk factors ( 21943158) Fast beta electroencephalogram ( 28070124) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FEV1/FVC) ( 30804560) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: COLQ SEC11A TRIM55 TRIM63	5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		590	23478
HPRD ID		01519	07503
Ensembl ID		ENSG00000114200	ENSG00000140612
Uniprot IDs		P06276	H0YKT4 P67812
PDB IDs		1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2PM8 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ 2XQK 2Y1K 3DJY 3DKK 3O9M 4AQD 4AXB 4B0O 4B0P 4BBZ 4BDS 4TPK 4XII 5DYT 5DYW 5DYY 5K5E 5LKR 5NN0 6EMI 6EP4 6EQP 6EQQ 6ESJ 6ESY 6EYF 6EZ2 6F7Q 6I0B 6I0C 6I2T 6QAA 6QAB 6QAC 6QAD 6QAE 6R6V 6R6W 6RUA 6SAM 6T9P 6T9S 6XTA 6ZWI 7AIY 7AMZ 7AWG 7AWH 7AWI 7BGC 7BO3 7BO4 7Q1M 7Q1N 7Q1O 7Q1P 7QBQ 7QBR 7QHD 7QHE 7ZPB 8AI7 8AM1 8AM2 8CGO 8QTW 8QTX 9EWU	7P2P
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Assembly At Neuromuscular Junction Acetylcholine Catabolic Process In Synaptic Cleft Skeletal Muscle Acetylcholine-gated Channel Clustering Acetylcholine Catabolic Process Response To Other Organism Response To External Biotic Stimulus Signal Peptide Processing Signal Peptidase Complex Ubiquitin Protein Ligase Activity Microtubule Diapedesis Muscle Atrophy Titin Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Contractile Muscle Fiber Striated Muscle Atrophy Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Glycolytic Process Synaptic Cleft Macrophage Migration M Band Negative Regulation Of ATP Metabolic Process Protein Ubiquitination Innate Immune Response Response To Electrical Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy Protein Modification By Small Protein Conjugation Negative Regulation Of Muscle Hypertrophy Defense Response To Symbiont Receptor Clustering Defense Response To Other Organism Regulation Of Glycolytic Process Post-translational Protein Modification Canonical NF-kappaB Signal Transduction
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