BCHE

Gene Name		butyrylcholinesterase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lumen Endoplasmic Reticulum Lumen Membrane Blood Microparticle
	Molecular Function	Beta-amyloid Binding Catalytic Activity Acetylcholinesterase Activity Cholinesterase Activity Enzyme Binding Choline Binding Identical Protein Binding
	Biological Process	Learning Negative Regulation Of Cell Proliferation Neuroblast Differentiation Choline Metabolic Process Response To Drug Response To Alkaloid Cellular Protein Metabolic Process Cocaine Metabolic Process Negative Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Folic Acid
Pathways		Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses
Drugs		Choline Tacrine Dipivefrin Pyridostigmine Galantamine Isoflurophate Pralidoxime Malathion Hexafluronium Demecarium Rivastigmine Edrophonium Echothiophate Mivacurium Beta-D-Mannose Diethylphosphono Group Methylphosphinic Acid Alpha-D-Mannose Butanoic Acid 9-N-Phenylmethylamino-Tacrine 2-(N-Morpholino)-Ethanesulfonic Acid Ethyl Dihydrogen Phosphate Butyrylthiocholine Monoisopropyl Ester Phosphonic Acid Group DODECANESULFONATE ION 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE (1R)-MENTHYL HEXYL PHOSPHONATE GROUP (1S)-MENTHYL HEXYL PHOSPHONATE GROUP ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Aspirin hydrolysis (plasma) ( 23508960) Butyrylcholinesterase levels ( 21862451) Cardiovascular disease risk factors ( 21943158) Heart failure ( 20445134)
Protein-protein Interactions		1 interactors: COLQ
Entrez ID		590
HPRD ID		01519
Ensembl ID		ENSG00000114200
Uniprot IDs		D3DNN4 P06276
PDB IDs		1EHO 1EHQ 1KCJ 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2PM8 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ 2XQK 2Y1K 3DJY 3DKK 3O9M 4AQD 4AXB 4B0O 4B0P 4BBZ 4BDS
Enriched GO Terms of Interacting Partners?		Acetylcholine Catabolic Process In Synaptic Cleft Acetylcholine Catabolic Process Synaptic Transmission, Cholinergic Neurotransmitter Catabolic Process Asymmetric Protein Localization Neurotransmitter Metabolic Process Regulation Of Neurotransmitter Levels
Tagcloud ?		3mum 4mum 90mum acetylcholinesterase ache bromophenyl butyrylcholinesterase carbamoyl chloro chlorosalicylic cholinesterases comparatively dialkyl dichlorophenyl diethyl eel electricus electrophorus ellman equine galantamine halogenated ic50s phenylcarbamoyl phosphates rivastigmine salicylanilide salicylic spectrophotometric