ARID1A and GATA1

Number of citations of the paper that reports this interaction (PubMedID 11018012)
56

Data Source:
BioGRID (pull down)

		ARID1A	GATA1
Description		AT-rich interaction domain 1A	GATA binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Bone Mineralization Negative Regulation Of Bone Mineralization Animal Organ Regeneration Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development System Development Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Sertoli Cell Development Primitive Erythrocyte Differentiation Platelet Aggregation Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Follicle-stimulating Hormone Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Positive Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591 30598549) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		19 interacting genes: ESR1 EWSR1 EZH2 FUS GATA1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 TAF15 TP53 TTC3	86 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PIAS4 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		8289	2623
HPRD ID		04319	02372
Ensembl ID		ENSG00000117713	ENSG00000102145
Uniprot IDs		O14497	P15976
PDB IDs		1RYU 6LTH 6LTJ	6G0Q
Enriched GO Terms of Interacting Partners?		Chromatin Nuclear Receptor-mediated Signaling Pathway Regulation Of DNA-templated Transcription Chromatin Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding Transcription Coactivator Binding Nuclear Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Glandular Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Growth Plate Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Biosynthetic Process Metal Ion Binding Transcription Regulator Complex Epithelial Cell Development Columnar/cuboidal Epithelial Cell Development Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA Transcription Nuclear Retinoid X Receptor Binding DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Development Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process NpBAF Complex NBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosome Disassembly Regulation Of G0 To G1 Transition Protein-DNA Complex Disassembly Transcription Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Brahma Complex RSC-type Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process BBAF Complex Protein Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Nucleoplasm Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of Double-strand Break Repair Regulation Of Myoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Differentiation Chromatin Remodeling
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