HYKK and LAGE3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HYKK	LAGE3
Description		hydroxylysine kinase	L antigen family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Kinase Activity Transferase Activity Amino Acid Kinase Activity Hydroxylysine Kinase Activity	Protein Binding
	Biological Process	Lysine Catabolic Process	TRNA Processing TRNA Threonylcarbamoyladenosine Metabolic Process
Pathways		Lysine catabolism	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Schizophrenia ( 29483656)
Interacting Genes		3 interacting genes: GMCL1 LAGE3 TRIP6	22 interacting genes: AKAP8L CYSRT1 GOLGA6L9 GON7 HSF2BP HYKK KRT40 KRTAP10-8 KRTAP6-3 MID2 MIPOL1 MKRN3 OSGEP PDE9A PLEKHJ1 PNMA1 POP7 PSMB9 TRIM23 TRIM27 TRIM55 VPS37C
Entrez ID		123688	8270
HPRD ID		12515	02087
Ensembl ID		ENSG00000188266	ENSG00000196976
Uniprot IDs		A2RU49	Q14657
PDB IDs			6GWJ
Enriched GO Terms of Interacting Partners?			EKC/KEOPS Complex TRNA Threonylcarbamoyladenosine Modification Ubiquitin Protein Ligase Activity Identical Protein Binding Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription TRNA Threonylcarbamoyladenosine Metabolic Process TRNA Processing Protein Ubiquitination Intermediate Filament Amino Acid Kinase Activity Hydroxylysine Kinase Activity Positive Regulation Of Autophagy Protein Modification By Small Protein Conjugation
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