SLIRP and WTAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLIRP	WTAP
Description		SRA stem-loop interacting RNA binding protein	WT1 associated protein
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Sperm Flagellum Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Membrane RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Mitochondrial RNA Catabolic Process Mitochondrion Organization Spermatid Development Single Fertilization Flagellated Sperm Motility Mitochondrial MRNA Polyadenylation Negative Regulation Of Mitochondrial MRNA Catabolic Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Modification
Pathways		Mitochondrial RNA degradation Mitochondrial mRNA modification	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS			Erosive tooth wear (severe vs non-severe) ( 29898447) Iron status biomarkers ( 19084217)
Interacting Genes		16 interacting genes: AMOT CCDC102B CSNK2A1 DMRTB1 EXOSC8 GOLGA6L9 KRT27 KRT31 KRT40 MTUS2 NDUFAB1 PICK1 PNMA1 RBPMS STK40 WTAP	19 interacting genes: ABHD15 BYSL CPNE1 EIF4ENIF1 EXOSC4 GTSE1 MAGEA11 OGT PSMA1 SLIRP SNCA TAB1 TCF12 TNIP1 VPS52 WT1 YWHAQ ZNF239 ZNF572
Entrez ID		81892	9589
HPRD ID		12639	09259
Ensembl ID		ENSG00000119705	ENSG00000146457
Uniprot IDs		A0A087WUN7 Q9GZT3	A0A087X1R4 Q15007
PDB IDs		8ANY	7VF2 7VF5 7YFJ 7YG4
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Structural Molecule Activity Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Intermediate Filament	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Cytoplasm Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Ectodermal Digestive Tract Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catabolic Process Negative Regulation Of Translation Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Short-chain Carboxylesterase Activity Regulation Of Neuron Differentiation Positive Regulation Of Gene Expression Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process
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