SF3A2 and LIN54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SF3A2	LIN54
Description		splicing factor 3a subunit 2	lin-54 DREAM MuvB core complex component
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm RNA Polymerase II Transcription Repressor Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Regulatory Region Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of Neuron Projection Development U2-type Prespliceosome Assembly	Regulation Of DNA-templated Transcription Nucleosome Organization
Pathways		mRNA Splicing - Major Pathway	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Myocardial infarction ( 24916648) Pulse pressure ( 26390057)	Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418 30224653) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		23 interacting genes: APBB1 ASPH BAIAP2 BEND2 CDC42 CEBPA GRB2 HTATSF1 LIN54 NCK2 OGT OSTF1 PRPF40A RCAN1 RETN SF3A1 SH3RF1 SMURF2 TCERG1 TFG TRIP10 VEZF1 YY1	7 interacting genes: BANP NFYC RB1 SF3A2 SP3 ZNF143 ZNF76
Entrez ID		8175	132660
HPRD ID		02877	13218
Ensembl ID		ENSG00000104897	ENSG00000189308
Uniprot IDs		Q05DF2 Q15428	Q6MZP7
PDB IDs		5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y53 6Y5Q 7ABG 7ABH 7ABI 7EVO 7ONB 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	5FD3
Enriched GO Terms of Interacting Partners?		Nuclear Speck Nucleoplasm Proline-rich Region Binding Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytoskeleton Organization Identical Protein Binding Response To Hormone Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization U2-type Prespliceosome MRNA Cis Splicing, Via Spliceosome Regulation Of Actin Filament Organization Cytoskeletal Anchor Activity Positive Regulation Of Organelle Organization U2-type Prespliceosome Assembly Regulation Of Developmental Process Regulation Of Actin Filament Polymerization U2 SnRNP Regulation Of Multicellular Organismal Process Nuclear Matrix U2-type Spliceosomal Complex Intracellular Signaling Cassette Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Actin Polymerization Or Depolymerization Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Actin Filament Length Vesicle Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly RNA Splicing Dendritic Spine Cytoplasm Neuron Projection Branch Point Positive Regulation Of Progesterone Secretion Regulation Of Proteolysis Positive Regulation Of Cell Communication Regulation Of Actin Filament-based Process Positive Regulation Of Signaling	Enucleate Erythrocyte Differentiation DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Protein-DNA Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Erythrocyte Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleoplasm PML Body Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization Positive Regulation Of SnRNA Transcription By RNA Polymerase II CCAAT-binding Factor Complex Glial Cell Apoptotic Process Rb-E2F Complex Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly MRNA 3'-splice Site Recognition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin/CDK Positive Transcription Elongation Factor Complex Embryonic Process Involved In Female Pregnancy Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding Transcription Regulator Complex Zinc Ion Binding Myeloid Cell Differentiation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Megakaryocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process
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