SF3A2

Description		splicing factor 3a subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of Neuron Projection Development U2-type Prespliceosome Assembly
Pathways		mRNA Splicing - Major Pathway
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Myocardial infarction ( 24916648) Pulse pressure ( 26390057)
Interacting Genes		23 interacting genes: APBB1 ASPH BAIAP2 BEND2 CDC42 CEBPA GRB2 HTATSF1 LIN54 NCK2 OGT OSTF1 PRPF40A RCAN1 RETN SF3A1 SH3RF1 SMURF2 TCERG1 TFG TRIP10 VEZF1 YY1
Entrez ID		8175
HPRD ID		02877
Ensembl ID		ENSG00000104897
Uniprot IDs		Q05DF2 Q15428
PDB IDs		5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y53 6Y5Q 7ABG 7ABH 7ABI 7EVO 7ONB 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Nuclear Speck Nucleoplasm Proline-rich Region Binding Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytoskeleton Organization Identical Protein Binding Response To Hormone Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization U2-type Prespliceosome MRNA Cis Splicing, Via Spliceosome Regulation Of Actin Filament Organization Cytoskeletal Anchor Activity Positive Regulation Of Organelle Organization U2-type Prespliceosome Assembly Regulation Of Developmental Process Regulation Of Actin Filament Polymerization U2 SnRNP Regulation Of Multicellular Organismal Process Nuclear Matrix U2-type Spliceosomal Complex Intracellular Signaling Cassette Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Actin Polymerization Or Depolymerization Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Actin Filament Length Vesicle Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly RNA Splicing Dendritic Spine Cytoplasm Neuron Projection Branch Point Positive Regulation Of Progesterone Secretion Regulation Of Proteolysis Positive Regulation Of Cell Communication Regulation Of Actin Filament-based Process Positive Regulation Of Signaling
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