LIN54 and ZNF143

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIN54	ZNF143
Description		lin-54 DREAM MuvB core complex component	zinc finger protein 143
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II Transcription Repressor Complex	Nucleus Nucleoplasm
	Molecular Function	Transcription Regulatory Region Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Nucleosome Organization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of SnRNA Transcription By RNA Polymerase II
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418 30224653) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)	Cutaneous squamous cell carcinoma ( 32041948) Height ( 31562340) Hip circumference ( 28552196)
Interacting Genes		7 interacting genes: BANP NFYC RB1 SF3A2 SP3 ZNF143 ZNF76	21 interacting genes: EAF1 ENKD1 EXOSC1 FAM90A1 FHL2 IL16 IQUB LIN54 LMO1 LMO3 NUDT22 POGZ SNRPB SPANXN3 SUOX TAB2 TCAF1 TSC22D2 YJU2 ZNF438 ZNF512B
Entrez ID		132660	7702
HPRD ID		13218	04578
Ensembl ID		ENSG00000189308	ENSG00000166478
Uniprot IDs		Q6MZP7	P52747
PDB IDs		5FD3
Enriched GO Terms of Interacting Partners?		Enucleate Erythrocyte Differentiation DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Protein-DNA Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Erythrocyte Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleoplasm PML Body Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization Positive Regulation Of SnRNA Transcription By RNA Polymerase II CCAAT-binding Factor Complex Glial Cell Apoptotic Process Rb-E2F Complex Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly MRNA 3'-splice Site Recognition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin/CDK Positive Transcription Elongation Factor Complex Embryonic Process Involved In Female Pregnancy Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding Transcription Regulator Complex Zinc Ion Binding Myeloid Cell Differentiation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Megakaryocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process
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