LIN54

Description		lin-54 DREAM MuvB core complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II Transcription Repressor Complex
	Molecular Function	Transcription Regulatory Region Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Nucleosome Organization
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418 30224653) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: BANP NFYC RB1 SF3A2 SP3 ZNF143 ZNF76
Entrez ID		132660
HPRD ID		13218
Ensembl ID		ENSG00000189308
Uniprot IDs		Q6MZP7
PDB IDs		5FD3
Enriched GO Terms of Interacting Partners?		Enucleate Erythrocyte Differentiation DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase III Protein-DNA Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Erythrocyte Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleoplasm PML Body Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization Positive Regulation Of SnRNA Transcription By RNA Polymerase II CCAAT-binding Factor Complex Glial Cell Apoptotic Process Rb-E2F Complex Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly MRNA 3'-splice Site Recognition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin/CDK Positive Transcription Elongation Factor Complex Embryonic Process Involved In Female Pregnancy Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding Transcription Regulator Complex Zinc Ion Binding Myeloid Cell Differentiation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Megakaryocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process
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