MIR141 and EDC4

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR141	EDC4
Description		microRNA 141	enhancer of mRNA decapping 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways			mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS			HDL cholesterol ( 21347282) Metabolic syndrome ( 22399527) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		87 interacting genes: ADARB1 APOBEC3B C1QBP CPSF7 DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP6 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NONO NUDT16L1 NUDT21 P3H1 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2B TRMT1L UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZNF346	42 interacting genes: CCL5 CDC42 CEBPA EIF2AK2 FBLN1 FXR1 FXR2 GIT2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-2 MIR141 MIR15B MIR199A1 MIR200A MIR200B MIR200C MIR205 MIR20A MIR21 MIR214 MIR222 MIR29C MIR34A MIR34C MIR363 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E SNCA SUMO2 YTHDC1
Entrez ID		406933	23644
HPRD ID			06911
Ensembl ID		ENSG00000207708	ENSG00000038358
Uniprot IDs			A0A8B0RAT7 Q6P2E9
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleus Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Spliceosomal Complex Nucleoplasm Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of RNA Catabolic Process MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule MRNA 3'-UTR Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation TRNA Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity MRNA 5'-UTR Binding Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Positive Regulation Of Gene Expression Regulation Of MRNA Stability RNA Transport Positive Regulation Of Cytoplasmic Translation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ligase Activity	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Signal Transduction Extracellular Space Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Angiogenesis Regulation Of Protein Metabolic Process Negative Regulation Of Vasculature Development Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Catabolic Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Population Proliferation Regulation Of Vasculature Development
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