PAPOLA and CPSF3

Number of citations of the paper that reports this interaction (PubMedID 8302877)
32

Data Source:
HPRD (in vitro)

		PAPOLA	CPSF3
Description		poly(A) polymerase alpha	cleavage and polyadenylation specific factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Manganese Ion Binding Metal Ion Binding Poly(A) RNA Polymerase Activity	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	MRNA Processing RNA 3'-end Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Cytosolic MRNA Polyadenylation	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Copper levels ( 26025379) Metabolite levels ( 23823483) Number of stillbirths in continuous marriage ( 30188897) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		6 interacting genes: CPSF1 CPSF3 FIP1L1 SMAD2 SNRPA YWHAE	10 interacting genes: CLP1 FAM107A HSPB1 MIR19A MIR19B1 MIR92A2 PAPOLA POLR2A RBBP6 YWHAG
Entrez ID		10914	51692
HPRD ID		10407	05825
Ensembl ID		ENSG00000090060	ENSG00000119203
Uniprot IDs		A0A0C4DGK1 G3XAH6 P51003	G5E9W3 Q9UKF6
PDB IDs		8R8R	2I7T 2I7V 6M8Q 6V4X 8T1Q 8T1R
Enriched GO Terms of Interacting Partners?		MRNA Cleavage And Polyadenylation Specificity Factor Complex RNA Processing MRNA Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway RNA Metabolic Process MRNA Metabolic Process RNA Binding Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Homomeric SMAD Protein Complex Regulation Of Heart Rate By Hormone Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Spliceosomal SnRNP Complex 5'-3' RNA Exonuclease Activity Odontoblast Differentiation Mesoderm Morphogenesis SMAD Protein Complex Pericardium Development Trophoblast Cell Migration U1 SnRNP Binding Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway MRNA 3'-end Processing By Stem-loop Binding And Cleavage Nucleus Heteromeric SMAD Protein Complex U1 SnRNA Binding Determination Of Left/right Asymmetry In Lateral Mesoderm Nucleoplasm Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Embryonic Foregut Morphogenesis Type I Transforming Growth Factor Beta Receptor Binding Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Ubiquitin Protein Ligase Binding Dorsal/ventral Axis Specification Endoderm Formation Calcium Channel Inhibitor Activity	Post-transcriptional Regulation Of Gene Expression Protein Kinase C Inhibitor Activity Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly RISC Complex Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Inflammatory Response To Antigenic Stimulus MRNA 3'-end Processing Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Immune Response Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Fibroblast Migration MRNA Metabolic Process Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Protein Kinase C Binding Positive Regulation Of Organ Growth Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Protein Secretion Positive Regulation Of Muscle Cell Differentiation
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